Fan Zaifeng, Smith Peter A, Eckstein Eugene C, Harris Gerald F
Orthopaedic and Rehabilitation Engineering Center, Marquette University, Milwaukee, Wisconsin, USA.
J Biomed Mater Res A. 2006 Oct;79(1):71-7. doi: 10.1002/jbm.a.30713.
Nanoindentation was used to characterize the intrinsic mechanical properties of bone tissue from eight (8) children with type III Osteogenesis Imperfecta (OI). The bone samples were harvested from the cortex portion at the site of bowing (the mid 2/3 of the shaft of the tibia/femur). Unlike normal bone tissue, OI type III cortical bone exhibited more isotropic material properties. Young's modulus and hardness values measured in the longitudinal direction did not show significant differences from the transverse measurements. No differences were observed in modulus or hardness in an analysis of the cortical and trabecular samples. The deformation patterns of the OI type III bone during nanoindentation were found to be similar to those of normal adult bone in an analysis of the ratio of modulus to hardness. No correlation was found between nanoindentation measurement and age in an analysis of regression.
采用纳米压痕技术对8名III型成骨不全症（OI）患儿的骨组织固有力学性能进行表征。骨样本取自弯曲部位（胫骨/股骨骨干中2/3）的皮质部分。与正常骨组织不同，III型OI皮质骨表现出更多各向同性的材料特性。在纵向测量的杨氏模量和硬度值与横向测量结果无显著差异。在对皮质和小梁样本的分析中，未观察到模量或硬度的差异。在对模量与硬度之比的分析中，发现III型OI骨在纳米压痕过程中的变形模式与正常成年骨相似。在回归分析中，未发现纳米压痕测量值与年龄之间存在相关性。
