Denton K M, Anderson W P
Baker Medical Research Institute, Prahran, Victoria, Australia.
Pflugers Arch. 1991 Oct;419(3-4):235-42. doi: 10.1007/BF00371101.
The determinants of glomerular ultrafiltration in superficial glomeruli of a strain of English cross-breed rabbits have been studied using micropuncture techniques. Mean arterial blood pressure in the anaesthetised rabbits was 70 +/- 2 mmHg. The glomerular filtration rate in the kidney prepared for micropuncture was 4.4 +/- 0.4 ml/min, the filtration fraction was 22 +/- 1% and renal blood flow was 33 +/- 3 ml/min, and these values were comparable to values in conscious rabbits. Glomerular capillary pressure (Pgc) averaged 31 +/- 1 mmHg, the single-nephron glomerular filtration rate (SNGFR) averaged 25 +/- 2 nl/min, and the mean ultrafiltration pressure (calculated using the whole-kidney filtration fraction) averaged 7 +/- 1 mmHg. A net positive pressure at the efferent end of the glomerular capillaries (4.4 +/- 0.9 mmHg) indicated that a state of filtration pressure disequilibrium existed, under the experimental conditions of this study, in rabbit glomeruli. The calculated glomerular ultrafiltration coefficient (Kf) was 0.08 +/- 0.01 nl s-1 mmHg-1. Thus, compared to the Munich-Wistar rat, SNGFR is lower in the rabbit. This reflects the substantially lower glomerular ultrafiltration pressure in the rabbit, although this was offset partially by a higher Kf.
利用微穿刺技术研究了一种英国杂交兔品系浅表肾小球的肾小球超滤决定因素。麻醉兔的平均动脉血压为70±2 mmHg。准备进行微穿刺的肾脏的肾小球滤过率为4.4±0.4 ml/min，滤过分数为22±1%，肾血流量为33±3 ml/min，这些值与清醒兔的值相当。肾小球毛细血管压力（Pgc）平均为31±1 mmHg，单肾单位肾小球滤过率（SNGFR）平均为25±2 nl/min，平均超滤压力（使用全肾滤过分数计算）平均为7±1 mmHg。肾小球毛细血管出端的净正压（4.4±0.9 mmHg）表明，在本研究的实验条件下，兔肾小球存在滤过压力不平衡状态。计算得出的肾小球超滤系数（Kf）为0.08±0.01 nl s-1 mmHg-1。因此，与慕尼黑-维斯塔尔大鼠相比，兔的SNGFR较低。这反映出兔的肾小球超滤压力显著较低，尽管这部分被较高的Kf所抵消。
