Horrobin D F
Efamol Research Institute, Kentville, Nova Scotia, Canada.
Prostaglandins Leukot Essent Fatty Acids. 1991 Oct;44(2):127-31. doi: 10.1016/0952-3278(91)90196-c.
Much attention has recently been paid to the possible benefits of increasing the intake of eicosapentaenoic acid (EPA) by consuming fish oil. However, this can have adverse effects such as raising cholesterol levels in patients with hyperlipidaemia and causing a deterioration in glucose tolerance. High doses of EPA given to Westerners also lower levels of dihomogammalinolenic acid (DGLA), a substance with a wide range of desirable cardiovascular and antiinflammatory actions. This lowering of DGLA does not occur in Eskimos who consume large amounts of EPA, indicating that there may be differences in essential fatty acid metabolism between Westerners and Eskimos. Therapeutic strategies are required which raise both EPA and DGLA and which do not raise EPA at the cost of lowering DGLA.
最近，人们对通过食用鱼油增加二十碳五烯酸（EPA）摄入量可能带来的益处给予了很多关注。然而，这可能会产生不良影响，如使高脂血症患者的胆固醇水平升高，并导致葡萄糖耐量恶化。给西方人服用高剂量的EPA还会降低二高-γ-亚麻酸（DGLA）的水平，DGLA是一种具有广泛有益心血管和抗炎作用的物质。在大量摄入EPA的爱斯基摩人中，DGLA水平不会降低，这表明西方人和爱斯基摩人在必需脂肪酸代谢方面可能存在差异。需要制定治疗策略，既能提高EPA和DGLA的水平，又不会以降低DGLA为代价来提高EPA。
