Horrobin D F
Med Hypotheses. 1987 Apr;22(4):421-8. doi: 10.1016/0306-9877(87)90037-5.
The low prevalences of CHD, psoriasis, asthma and rheumatoid arthritis in Eskimos have been attribute to the high dietary intake of EPA from fish and marine mammals. However, even on a Western diet, Eskimos have plasma arachidonic acid (AA) levels far below those seen in Europeans while dihomogammalinolenic acid (DGLA) levels are higher in Eskimos. These low AA and high DGLA levels seem to be due to a genetic abnormality in EFA desaturation since they are found even when EPA intakes are low. Since AA is known to be important in the pathogenesis of CHD, asthma, psoriasis and arthritis, while DGLA has properties which make it of likely therapeutic value in these conditions, the genetically high DGLA and low AA are likely to be as important as dietary EPA in determining Eskimo disease patterns.
爱斯基摩人冠心病、牛皮癣、哮喘和类风湿性关节炎的低发病率归因于从鱼类和海洋哺乳动物中大量摄入二十碳五烯酸（EPA）。然而，即使采用西方饮食，爱斯基摩人的血浆花生四烯酸（AA）水平也远低于欧洲人，而二高-γ-亚麻酸（DGLA）水平在爱斯基摩人中更高。这些低AA和高DGLA水平似乎是由于必需脂肪酸去饱和的基因异常，因为即使EPA摄入量低时也能发现这种情况。由于已知AA在冠心病、哮喘、牛皮癣和关节炎的发病机制中很重要，而DGLA具有在这些病症中可能具有治疗价值的特性，因此从基因角度来看，高DGLA和低AA在决定爱斯基摩人的疾病模式方面可能与饮食中的EPA同样重要。
