Donelli Gianfranco, Guaglianone Emilio, Di Rosa Roberta, Fiocca Fausto, Basoli Antonio
Department of Technologies and Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.
Clin Med Res. 2007 Mar;5(1):53-60. doi: 10.3121/cmr.2007.683.
Endoscopic biliary stenting is today the most common palliative treatment for patients suffering from obstructive jaundice associated with malignant hepatobiliary tumors or benign strictures. However, recurrent jaundice, with or without cholangitis, is a major complication of a biliary endoprosthesis insertion. Thus, stent removal and replacement with a new one frequently occurs as a consequence of device blockage caused by microbial biofilm growth and biliary sludge accumulation in the lumen. Factors and mechanisms involved in plastic stent clogging arising from epidemiological, clinical and experimental data, as well as the possible strategies to prevent biliary stent failure, will be reviewed and discussed.
内镜下胆道支架置入术是目前治疗恶性肝胆肿瘤或良性狭窄所致梗阻性黄疸患者最常用的姑息治疗方法。然而，无论有无胆管炎，复发性黄疸都是胆道内支架置入术的主要并发症。因此，由于微生物生物膜生长和管腔内胆汁淤积导致装置堵塞，常常需要取出支架并更换新的支架。本文将回顾和讨论基于流行病学、临床和实验数据的塑料支架堵塞相关因素及机制，以及预防胆道支架功能障碍的可能策略。
