Butler Alexandra E, Huang Andrew, Rao P Nagesh, Bhushan Anil, Hogan William J, Rizza Robert A, Butler Peter C
University of California Los Angeles, Larry L. Hillblom Islet Research Center, 900 Veteran Ave., Los Angeles, CA 90095-7073, USA.
Diabetes. 2007 Jul;56(7):1810-6. doi: 10.2337/db06-1385. Epub 2007 Apr 24.
Type 1 and type 2 diabetes are characterized by an approximately 98 and approximately 65% loss of pancreatic beta-cells, respectively. Efforts to reverse either form of diabetes increasingly focus on the possibility of promoting beta-cell replacement and/or regeneration. Islet transplantation has been explored, but it does not provide long-term insulin independence. One possible source of beta-cell regeneration is hematopoietic stem cells. In mice, there are conflicting data as to whether hematopoietic stem cells contribute to pancreatic beta-cells. We sought to establish whether hematopoietic stem cells (derived from adult donors) transdifferentiate into pancreatic beta-cells in adult humans.
We addressed this in 31 human pancreata obtained at autopsy from hematopoietic stem cell transplant recipients who had received their transplant from a donor of the opposite sex.
Whereas some donor-derived cells were observed in the nonendocrine pancreata, no pancreatic beta-cells were identified that were derived from donor hematopoietic stem cells, including two cases with type 2 diabetes.
We conclude that hematopoietic stem cells derived from adult donors contribute minimally to pancreatic beta-cells in nondiabetic adult humans. These data do not rule out the possibility that hematopoietic stem cells contribute to pancreatic beta-cells in childhood or in individuals with type 1 diabetes.
1型和2型糖尿病的特征分别是胰腺β细胞约98%和约65%的损失。逆转任何一种糖尿病形式的努力越来越多地集中在促进β细胞替代和/或再生的可能性上。胰岛移植已被探索，但它不能提供长期的胰岛素非依赖状态。β细胞再生的一个可能来源是造血干细胞。在小鼠中，关于造血干细胞是否有助于胰腺β细胞存在相互矛盾的数据。我们试图确定（来自成年供体的）造血干细胞在成年人类中是否会转分化为胰腺β细胞。
我们对31个从造血干细胞移植受者尸检中获得的人类胰腺进行了研究，这些受者接受的是来自异性供体的移植。
虽然在非内分泌胰腺中观察到了一些供体来源的细胞，但未发现源自供体造血干细胞的胰腺β细胞，包括两例2型糖尿病患者。
我们得出结论，成年供体来源的造血干细胞对非糖尿病成年人类的胰腺β细胞贡献极小。这些数据不排除造血干细胞在儿童期或1型糖尿病患者中对胰腺β细胞有贡献的可能性。
