Sakeni Riyadh A, Al-Nimer Marwan S M
Department of Medicine, College of Medicine, Al-Mustansiriya University, Baghdad, Iraq.
Saudi Med J. 2007 May;28(5):707-12.
To compare the effectiveness of triamcinolone acetonide (40 mg) and methylprednisolone acetate (60 mg) in Iraqi patients with primary and secondary frozen shoulder.
A total number of 135 (93 males and 42 females) patients with frozen shoulder, allocated at outpatient clinic of rheumatology in Al-Yarmook Teaching Hospital (Baghdad-Iraq) from January 2004 to December 2005, were enrolled in non-controlled clinical trial. The diagnosis of frozen shoulder was made using the guidelines for shoulder complaint issued by the Dutch College of General Practitioners. Intraarticular injections of 40 mg triamcinolone acetonide (46 males and 22 females) or 60 mg methylprednisolone acetate (47 males and 20 females) were given every 3 weeks (not more than 3 injections) by using posterior route.
Both triamcinolone acetonide (81.8%) and methylprednisolone acetate (83.3%) were equally effective in primary frozen shoulder. Triamcinolone acetonide is significantly improved diabetic frozen shoulder in comparison to methylprednisolone acetate (69% versus 39%). Also patients on triamcinolone acetonide required less number of steroid injections and higher percent of severe cases were significantly improved by triamcinolone acetonide in comparison with methylprednisolone acetate.
We conclude that triamcinolone acetonide is a good rescue for painful stiff shoulder particularly for resistant cases as with diabetes mellitus, and with long duration of illness. Also, its efficacy can be observed with less frequent injections.
比较曲安奈德(40毫克)和醋酸甲泼尼龙(60毫克)对伊拉克原发性和继发性肩周炎患者的疗效。
2004年1月至2005年12月在阿尔亚穆克教学医院(伊拉克巴格达)风湿病门诊就诊的135例肩周炎患者(93例男性,42例女性)纳入非对照临床试验。肩周炎的诊断采用荷兰全科医生学院发布的肩部疾病指南。采用后路,每3周关节内注射40毫克曲安奈德(46例男性,22例女性)或60毫克醋酸甲泼尼龙(47例男性,20例女性)(不超过3次注射)。
曲安奈德(81.8%)和醋酸甲泼尼龙(83.3%)对原发性肩周炎的疗效相当。与醋酸甲泼尼龙相比,曲安奈德对糖尿病性肩周炎有显著改善(69%对39%)。此外,与醋酸甲泼尼龙相比,使用曲安奈德的患者所需的类固醇注射次数更少,曲安奈德使更高比例的重症病例得到显著改善。
我们得出结论,曲安奈德是治疗疼痛性僵硬肩部的良好药物,特别是对于糖尿病等耐药病例以及病程较长的病例。此外,注射频率较低时也可观察到其疗效。