de Jong B A, Dahmen R, Hogeweg J A, Marti R K
Department of Rehabilitation Medicine, Academic Medical Centre, University of Amsterdam, The Netherlands.
Clin Rehabil. 1998 Jun;12(3):211-5. doi: 10.1191/026921598673772420.
Although corticosteroid injections have been reported to be effective in capsulitis of the shoulder, the optimal dose has not been established. The purpose of this study was to compare relief of symptoms following a lower dose with that following a higher dose of triamcinolone acetonide given intra-articularly.
Thirty-two patients were given low dose suspension; 25 patients were given high dose suspension.
Randomized, double-blind clinical trial. Each patient was given a course of three injections. Pain, sleep disturbance, functional impairment and passive range of motion (ROM) were assessed at intake and at one, three and six weeks after the initial injection. Data were analysed by independent sample t-tests and nonparametric Mann-Whitney U-tests.
The group which received the 40 mg dose showed significantly greater improvement than the group receiving the 10 mg dose.
The study shows that in the treatment of frozen shoulder greater symptom relief is obtained with a dose of 40 mg triamcinolone acetonide intra-articularly than with a dose of 10 mg. The effect on pain and sleep disturbance was more marked than on ROM. Intra-articular injections with triamcinolone acetonide appear to be an effective method to obtain symptom relief for patients with painful capsulitis of the shoulder.
尽管已有报道称皮质类固醇注射对肩周炎有效，但最佳剂量尚未确定。本研究的目的是比较关节腔内注射低剂量与高剂量曲安奈德后症状缓解情况。
32例患者接受低剂量混悬液注射；25例患者接受高剂量混悬液注射。
随机双盲临床试验。每位患者接受一个疗程的三次注射。在初次注射时以及注射后1周、3周和6周评估疼痛、睡眠障碍、功能损害和被动活动范围（ROM）。数据采用独立样本t检验和非参数曼-惠特尼U检验进行分析。
接受40mg剂量的组比接受10mg剂量的组改善更显著。
该研究表明，在治疗冻结肩时，关节腔内注射40mg曲安奈德比注射10mg能获得更大程度的症状缓解。对疼痛和睡眠障碍的影响比对ROM的影响更明显。关节腔内注射曲安奈德似乎是缓解肩部疼痛性关节囊炎患者症状的有效方法。
