Science Integration Division, Public Health Agency of Canada (PHAC), 785 Carling Ave,, Ottawa, ON, K1A 0K9, Canada.
Infect Agent Cancer. 2013 Jul 1;8(1):25. doi: 10.1186/1750-9378-8-25.
Certain types of the Human Papillomavirus (HPV) are sexually transmitted and highly associated with development of cervical dysplasia and cervical cancer but the distribution of HPV infection in the North, particularly amongst First Nations, Metis, and Inuit peoples, is little known. The purposes of the study are to identify the prevalence of type-specific HPV infections and the association of different HPV types with cervical dysplasia among women in Northern Canada.
This was a cross-sectional study with attendants of the routine or scheduled Pap testing program in the Northwest Territories (NWT), Nunavut, Labrador and Yukon, Canada. Approximately half of each sample was used for Pap test and the remaining was used for HPV genotyping using a Luminex-based method. Pap test results, HPV types, and demographic information were linked for analyses.
Results from 14,598 specimens showed that HPV infection was approximately 50% higher among the Aboriginal than the non-Aboriginal population (27.6% vs. 18.5%). Although the most common HPV type detected was HPV 16 across region, the prevalence of other high risk HPV types was different. The age-specific HPV prevalence among Aboriginal showed a 'U' shape which contrasted to non-Aboriginal. The association of HPV infection with cervical dysplasia was similar in both Aboriginal and non-Aboriginal populations.
The HPV prevalence was higher in Northern Canada than in other Areas in Canada. The prevalence showed a higher rate of other high risk HPV infections but no difference of HPV 16/18 infections among Aboriginal in comparison with non-Aboriginal women. This study provides baseline information on HPV prevalence that may assist in surveillance and evaluation systems to track and assess HPV vaccine programs.
某些类型的人乳头瘤病毒（HPV）通过性传播，与宫颈发育不良和宫颈癌的发展高度相关，但 HPV 感染在北方的分布情况，尤其是在第一民族、梅蒂斯人和因纽特人中，知之甚少。本研究的目的是确定 HPV 感染的流行情况以及不同 HPV 类型与加拿大北部女性宫颈发育不良的相关性。
这是一项横断面研究，对象为加拿大西北地区、努纳武特地区、拉布拉多地区和育空地区常规或定期巴氏涂片检查计划的参与者。每个样本的大约一半用于巴氏涂片检查，其余的则用于使用基于 Luminex 的方法进行 HPV 基因分型。对巴氏涂片检查结果、HPV 类型和人口统计学信息进行了关联分析。
来自 14598 份标本的结果显示，土著人群的 HPV 感染率比非土著人群高约 50%（27.6%比 18.5%）。尽管在所有地区最常见的 HPV 类型都是 HPV 16，但其他高危 HPV 类型的流行率不同。土著人群中 HPV 流行率呈现出“U”形，与非土著人群不同。HPV 感染与宫颈发育不良的相关性在土著人群和非土著人群中相似。
与加拿大其他地区相比，加拿大北部 HPV 感染率更高。该地区的 HPV 感染率显示出其他高危 HPV 感染率更高，但与非土著女性相比，土著人群中 HPV 16/18 的感染率没有差异。本研究提供了 HPV 流行率的基线信息，这可能有助于监测和评估系统，以跟踪和评估 HPV 疫苗接种计划。
