Nebe J G Barbara, Luethen Frank, Lange Regina, Beck Ulrich
Department of Internal Medicine, University of Rostock, BMFZ, Schillingallee 69, D-18057 Rostock, Germany.
Macromol Biosci. 2007 May 10;7(5):567-78. doi: 10.1002/mabi.200600293.
Cellular behavior at the interface of an implant is influenced by the material's topography. However, little is known about the correlation between the biological parameters and the physicochemical characteristics of the biomaterial. We therefore modified pure titanium surfaces by polishing, machining, blasting with glass spheres, blasting with corundum particles, and vacuum plasma spraying to give progressively higher surface roughness. The material surface was characterized by SEM, surface profiling, and electrochemical methods. We revealed a correlation for integrin expression and formation, adhesion, spreading, proliferation, and bone sialo protein expression with the physicochemical parameters of the titanium surfaces.
植入物界面处的细胞行为受材料表面形貌的影响。然而，关于生物参数与生物材料的物理化学特性之间的相关性，我们所知甚少。因此，我们通过抛光、机械加工、用玻璃珠喷砂、用刚玉颗粒喷砂以及真空等离子喷涂对纯钛表面进行改性，以使表面粗糙度逐渐增加。通过扫描电子显微镜（SEM）、表面轮廓分析和电化学方法对材料表面进行表征。我们揭示了钛表面的物理化学参数与整合素表达和形成、黏附、铺展、增殖以及骨唾液蛋白表达之间的相关性。
