Hammer Gianna Elena, Kanaseki Takayuki, Shastri Nilabh
Division of Immunology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720-3200, USA.
Immunity. 2007 Apr;26(4):397-406. doi: 10.1016/j.immuni.2007.04.003.
Major histocompatibility complex (MHC) class I molecules present short, perfectly cleaved peptides on the cell surface for immune surveillance by CD8(+) T cells. The pathway for generating these peptides begins in the cytoplasm, and the peptide-MHC I (pMHC I) repertoire is finalized in the endoplasmic reticulum. Recent studies show that the peptides for MHC I are customized by the ER aminopeptidase associated with antigen processing and by dynamic interactions within the MHC peptide-loading complex. Failure to customize the pMHC I repertoire has profound immunological consequences.
主要组织相容性复合体（MHC）I类分子在细胞表面呈递经过完美切割的短肽，以供CD8(+) T细胞进行免疫监视。生成这些肽的途径始于细胞质，肽-MHC I（pMHC I）库在内质网中最终确定。最近的研究表明，MHC I的肽是由与抗原加工相关的内质网氨肽酶以及MHC肽装载复合物内的动态相互作用定制的。未能定制pMHC I库会产生深远的免疫学后果。
