Balistreri Carmela Rita, Caruso Calogero, Grimaldi Maria Paola, Listì Florinda, Vasto Sonya, Orlando Valentina, Campagna Anna Maria, Lio Domenico, Candore Giuseppina
Gruppo di Studio sull'Immunosenescenza, Dipartimento di Biopatologia e Metodologie Biomediche, Corso Tukory 211, 90134 Palermo, Italy.
Ann N Y Acad Sci. 2007 Apr;1100:162-72. doi: 10.1196/annals.1395.014.
The CC chemokine receptor 5 (CCR5) is a member of CC-chemokine receptor family. CCR5 has the characteristic structure of a seven transmembrane G protein-coupled receptor (GPCR), which regulates trafficking and effector functions of memory/effector Th1 cells, macrophages, NK cells, and immature dendritic cells. CCR5 and its ligands are important molecules in viral pathogenesis. CCR5 represents the co-receptor for macrophage (M) and dual (T cell and M)-tropic immunodeficiency viruses. Recent evidence has also demonstrated the role of CCR5 in a variety of human diseases, ranging from infectious and inflammatory diseases to cancer. In this article, we describe the involvement of CCR5 in two age-related diseases, atherosclerosis and Alzheimer's disease, suggesting a possible role of chemokine system on these diseases' pathophysiology. Finally, we review the data on the probable association between CCR5Delta32 deletion and cardiovascular diseases and Alzheimer's disease.
C-C趋化因子受体5（CCR5）是C-C趋化因子受体家族的成员。CCR5具有七跨膜G蛋白偶联受体（GPCR）的特征结构，可调节记忆/效应Th1细胞、巨噬细胞、自然杀伤细胞和未成熟树突状细胞的运输及效应功能。CCR5及其配体是病毒发病机制中的重要分子。CCR5是巨噬细胞（M）嗜性和双嗜性（T细胞和M嗜性）免疫缺陷病毒的共受体。最近的证据还表明CCR5在多种人类疾病中发挥作用，范围从感染性和炎症性疾病到癌症。在本文中，我们描述了CCR5在两种与年龄相关的疾病——动脉粥样硬化和阿尔茨海默病中的作用，提示趋化因子系统在这些疾病病理生理学中可能发挥的作用。最后，我们综述了关于CCR5Δ32缺失与心血管疾病和阿尔茨海默病之间可能关联的数据。
