化脓性汗腺炎与锌：一种新的治疗方法。一项试点研究。
Hidradenitis suppurativa and zinc: a new therapeutic approach. A pilot study.
作者信息
Brocard Anabelle, Knol Anne-Chantal, Khammari Amir, Dréno Brigitte
机构信息
Department of Dermatology, INSERM U601, CHU Hôtel-Dieu, Nantes, France.
出版信息
Dermatology. 2007;214(4):325-7. doi: 10.1159/000100883.
BACKGROUND
Hidradenitis suppurativa (Verneuil's disease) is a chronic suppurative dermatosis involving apocrine glands with a severe impact on the quality of life, which is enhanced by the fact that the drugs usually prescribed are poorly effective.
OBJECTIVE
We discuss a new therapeutic approach based on zinc salts.
METHODS
We performed a pilot study on 22 patients, mainly from grade I or II in Hurley's classification. All included patients had previously been prescribed a treatment (antibiotic, isotretinoin, surgery or anti-androgens), which was inefficient. They were then treated with 90 mg of zinc gluconate per day (15 mg zinc per Rubozinc capsule).
RESULTS
We observed a clinical response in all patients, with 8 complete remissions (CR) and 14 partial remissions (PR). When CR was obtained, the treatment was progressively decreased (average of 3.5 capsules/day); 4/22 patients experienced side-effects, mainly gastro-intestinal.
CONCLUSION
Zinc salts could provide a new therapeutic alternative for the treatment of hidradenitis suppurativa.
背景
化脓性汗腺炎（韦尔内伊病）是一种累及顶泌汗腺的慢性化脓性皮肤病，对生活质量有严重影响，而通常所开药物疗效不佳这一事实更是加剧了这种影响。
目的
我们讨论一种基于锌盐的新治疗方法。
方法
我们对22例患者进行了一项初步研究，这些患者主要为赫尔利分级中的I级或II级。所有纳入患者此前都接受过一种治疗（抗生素、异维A酸、手术或抗雄激素药物），但均无效。然后他们每天服用90毫克葡萄糖酸锌（每粒鲁博锌胶囊含15毫克锌）。
结果
我们观察到所有患者均有临床反应，8例完全缓解（CR），14例部分缓解（PR）。当获得完全缓解时，治疗剂量逐渐减少（平均每天3.5粒胶囊）；22例患者中有4例出现副作用，主要是胃肠道方面的。
结论
锌盐可为化脓性汗腺炎的治疗提供一种新的治疗选择。
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