Ulvestad Bente, Randem Britt Grethe, Hetland Siri, Sigurdardottir Gudmunda, Johannessen Egil, Lyberg Torstein
Mesta AS, PO Box 5133, N-1503 Moss, Norway.
Scand J Work Environ Health. 2007 Apr;33(2):114-21. doi: 10.5271/sjweh.1114.
The aim of this study was to determine the association between exposures in asphalt work and changes in lung function, blood concentrations of interleukin-6 (IL-6), micro-C-reactive protein, and fibrinogen among asphalt workers during a work season.
Blood samples from all asphalt workers (N=140) in Norway's largest road construction and maintenance company were taken in April-May 2005 and again in September-October 2005. Spirometric tests of the asphalt workers and a reference group (heavy construction workers, N=126) were carried out before the asphalt season, and the asphalt workers were tested again at the end of the season. Exposure to total dust, oil mist, polycyclic aromatic hydrocarbons, and gases was measured by personal samplers during the asphalt season.
The asphalt workers had a significantly a lower forced expiratory volume in 1 second (FEV(1)) and forced expiratory flow rate of 50% of the forced vital capacity than the reference group at the beginning of the season. The asphalt workers were divided according to their exposure into two groups, asphalt pavers (N=81) and asphalt plant operators and truck drivers (N=54). The screedmen, a group of the asphalt pavers, had a statistically significant lower FVC and FEV(1) after one season of asphalt work than all of the other asphalt workers (P<0.05). The mean plasma concentration of IL-6 increased among the asphalt pavers from 1.55 pg/ml before the season to 2.67 pg/ml at the season's end (P=0.04, adjusted for current smoking).
Exposure in asphalt paving may enhance the risk of lung function decline.
本研究旨在确定沥青作业暴露与沥青工人在一个工作季期间肺功能变化、血液中白细胞介素 - 6（IL - 6）、微量C反应蛋白和纤维蛋白原浓度之间的关联。
对挪威最大的道路建设和维护公司的所有沥青工人（N = 140）于2005年4月至5月采集血样，并于2005年9月至10月再次采集。在沥青作业季开始前，对沥青工人和一个参照组（重型建筑工人，N = 126）进行了肺量计测试，沥青工人在作业季结束时再次接受测试。在沥青作业季期间，通过个人采样器测量了总粉尘、油雾、多环芳烃和气体的暴露情况。
在作业季开始时，沥青工人的1秒用力呼气量（FEV(1)）和用力肺活量50%时的用力呼气流量显著低于参照组。根据暴露情况，沥青工人被分为两组，沥青摊铺机操作员（N = 81）和沥青厂操作员及卡车司机（N = 54）。熨平工，作为沥青摊铺机操作员中的一组，在经过一个沥青作业季后，其用力肺活量（FVC）和1秒用力呼气量（FEV(1)）在统计学上显著低于所有其他沥青工人（P < 0.05）。沥青摊铺机操作员中，血浆IL - 6的平均浓度从作业季开始前的1.55 pg/ml增加到作业季结束时的2.67 pg/ml（P = 0.04，经当前吸烟情况校正）。
沥青铺路作业中的暴露可能会增加肺功能下降的风险。
