克拉拉细胞蛋白作为沥青工人肺上皮损伤的生物标志物。
Clara cell protein as a biomarker for lung epithelial injury in asphalt workers.
作者信息
Ulvestad Bente, Randem Britt Grethe, Andersson Lena, Ellingsen Dag G, Barregard Lars
机构信息
Department of Occupational Medicine, Mesta AS, Moss, Norway.
出版信息
J Occup Environ Med. 2007 Oct;49(10):1073-8. doi: 10.1097/JOM.0b013e3181570726.
OBJECTIVE
We investigated if asphalt workers showed signs of lung epithelial injury as shown by increased Clara cell protein 16 (CC16) in serum after 6 months of exposure.
METHODS
Asphalt pavers, asphalt plant operators, and asphalt engineers underwent lung function tests and blood samples before the start of the asphalt season. The tests were repeated before the end of the asphalt season. Blood samples were analyzed for concentration of CC16 and interleukin-6 (IL-6).
RESULTS
After adjustment for current smoking, the pavers had a significantly larger increase in CC16 concentrations after the season as compared with that of the engineers and plant operators. In pavers, the change in serum CC16 was correlated with the change in IL-6.
CONCLUSION
CC16 increased over the season in pavers and appears to be a useful biomarker for lung epithelial injury in exposed workers.
目的
我们研究了沥青工人在接触沥青6个月后，血清中克拉拉细胞蛋白16（CC16）升高是否表明存在肺上皮损伤迹象。
方法
在沥青作业季节开始前，对沥青摊铺机操作人员、沥青厂操作员和沥青工程师进行肺功能测试并采集血样。在沥青作业季节结束前重复进行测试。分析血样中CC16和白细胞介素-6（IL-6）的浓度。
结果
在对当前吸烟情况进行校正后，与工程师和工厂操作员相比，摊铺机操作人员在作业季节后CC16浓度的升高幅度显著更大。在摊铺机操作人员中，血清CC16的变化与IL-6的变化相关。
结论
摊铺机操作人员在作业季节中CC16升高，它似乎是接触沥青工人肺上皮损伤的一个有用生物标志物。
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