National Institute of Occupational Health, Oslo, Norway.
Biomarkers. 2010 Sep;15(6):498-507. doi: 10.3109/1354750X.2010.490305.
Pneumoproteins, biomarkers of systemic inflammation and endothelial activation were studied across a season in 72 asphalt pavers, 32 asphalt plant operators and 19 asphalt engineers. Smokers had lower concentrations of Clara cell protein (CC-16) and surfactant protein A, but higher concentrations of surfactant protein D, interleukin 6, C-reactive protein, fibrinogen and intercellular adhesion molecule (ICAM)-1 than non-smokers. Smokers reporting wheezing had lower mean CC-16 concentration than smokers not reporting wheezing (5.7 vs 8.6 microg l(-1); p = 0.05). Cholesterol, P-selectin and ICAM-1 were lower in pavers and operators at the end compared with the start of the season. This may be related to increased physical activity during the season.
在一个季节中，研究了 72 名沥青摊铺机工人、32 名沥青厂操作员和 19 名沥青工程师的肺保护蛋白、全身炎症和内皮细胞激活的生物标志物。与不吸烟者相比，吸烟者的克拉拉细胞蛋白 (CC-16) 和表面活性剂蛋白 A 的浓度较低，但表面活性剂蛋白 D、白细胞介素 6、C 反应蛋白、纤维蛋白原和细胞间黏附分子 (ICAM)-1 的浓度较高。报告喘息的吸烟者的平均 CC-16 浓度低于不报告喘息的吸烟者（5.7 与 8.6μg l(-1)；p=0.05）。与季节开始时相比，在赛季结束时，铺路工和操作人员的胆固醇、P-选择素和 ICAM-1 较低。这可能与赛季期间体力活动增加有关。
