Köhler U, Martin R, Krug H, Bilek K
Klinik für Gynäkologie und Geburtshilfe, Leipzig, Bundesrepublik, Deutschland.
Zentralbl Gynakol. 1991;113(20):1086-95.
In a prospective investigation the concentration of DNA (ploidy) and of steroid hormone receptors (ER and PgR, resp.) were studied in endometrial carcinoma and related to each other, to established morphological prognostic criteria (stage, typing, grading, relative invasion of myometrium), and to the clinical progress of disease, respectively. The microscopic spectrophotometric analysis of DNA showed diploid main lines in 2/3 of investigated endometrial carcinoma. It could be demonstrated a relationship between heteroploidy, decreased mean concentrations of ER and PgR, unfavourable prognostic factors (stage II-IV, G3, myometrial invasion of greater than 2/3) and clinical progress of disease. The mean value of ER and PgR was higher in diploid carcinoma than in heteroploid ones. Significant differences were found both in the relation of the PgR concentration to different tumor stages (stage I vs. II-IV) and of the concentration to the different types of ploidy. Exceeding the histological differentiation, the determination of DNA and ER/PgR receptors can results in additional prognostic informations for a scientific proved, adjuvant or curative strategy of therapy after the operation.
在一项前瞻性研究中，对子宫内膜癌中DNA（倍体）和类固醇激素受体（分别为ER和PgR）的浓度进行了研究，并将它们相互关联，还分别与既定的形态学预后标准（分期、分型、分级、肌层相对浸润情况）以及疾病的临床进展相关联。DNA的显微分光光度分析显示，在所研究的子宫内膜癌中，三分之二呈现二倍体主线。可以证明异倍体、ER和PgR平均浓度降低、不良预后因素（II - IV期、G3、肌层浸润大于三分之二）与疾病临床进展之间存在关联。二倍体癌中ER和PgR的平均值高于异倍体癌。在PgR浓度与不同肿瘤分期（I期与II - IV期）的关系以及浓度与不同倍体类型的关系方面均发现了显著差异。除了组织学分化外，DNA和ER/PgR受体的测定可为术后经过科学验证的辅助或根治性治疗策略提供额外的预后信息。
