癌症是异常染色质结构的一种表现形式。
Cancer as a manifestation of aberrant chromatin structure.
作者信息
Brock Malcolm V, Herman James G, Baylin Stephen B
机构信息
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21205-2196, USA.
出版信息
Cancer J. 2007 Jan-Feb;13(1):3-8. doi: 10.1097/PPO.0b013e31803c5415.
Abstract
In this article we review many important epigenetic changes in early carcinogenesis and discuss the possibility of these alterations being targeted for therapeutic intervention in the future. Both regional DNA methylation and global chromatin packaging are interrelated partners that function in concert to control gene transcription. We first summarize briefly DNA methylation and its role in gene expression. Then, we focus on how the DNA is packaged into chromatin and the tight relationship between chromatin and DNA methylation. A more complete understanding of these key, regulatory events is vital in approaching a more rational drug therapy to various malignancies.
摘要
在本文中，我们回顾了早期致癌过程中许多重要的表观遗传变化，并讨论了未来将这些改变作为治疗干预靶点的可能性。区域DNA甲基化和整体染色质包装是相互关联的伙伴，它们协同发挥作用以控制基因转录。我们首先简要总结DNA甲基化及其在基因表达中的作用。然后，我们重点关注DNA如何包装成染色质以及染色质与DNA甲基化之间的紧密关系。更全面地了解这些关键的调控事件对于制定针对各种恶性肿瘤的更合理药物治疗至关重要。
相似文献
1
Cancer as a manifestation of aberrant chromatin structure.癌症是异常染色质结构的一种表现形式。
Cancer J. 2007 Jan-Feb;13(1):3-8. doi: 10.1097/PPO.0b013e31803c5415.
2
Epigenetic tête-à-tête: the bilateral relationship between chromatin modifications and DNA methylation.表观遗传学的深入探讨：染色质修饰与DNA甲基化之间的双向关系
Biochem Cell Biol. 2006 Aug;84(4):463-76. doi: 10.1139/o06-090.
3
DNA methylation: the nuts and bolts of repression.DNA甲基化：基因抑制的基本原理
J Cell Physiol. 2007 Nov;213(2):384-90. doi: 10.1002/jcp.21224.
4
[DNA methylation: an epigenetic process of medical importance].[DNA甲基化：一个具有医学重要性的表观遗传过程]
Rev Invest Clin. 2004 Jan-Feb;56(1):56-71.
5
Identification of driver and passenger DNA methylation in cancer by epigenomic analysis.通过表观基因组分析鉴定癌症中的驱动和乘客 DNA 甲基化。
Adv Genet. 2010;70:277-308. doi: 10.1016/B978-0-12-380866-0.60010-1.
6
Epigenetic analysis in the search for tumor suppressor genes.寻找肿瘤抑制基因中的表观遗传学分析
Epigenomics. 2010 Aug;2(4):489-93. doi: 10.2217/epi.10.29.
7
Cancer and epigenesis: a developmental perspective.癌症与表观遗传学：发育视角
Adv Pediatr. 2003;50:59-80.
8
Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer.多梳蛋白介导的组蛋白H3赖氨酸27位点甲基化在癌症中为基因从头甲基化预先标记。
Nat Genet. 2007 Feb;39(2):232-6. doi: 10.1038/ng1950. Epub 2006 Dec 31.
9
Epigenetics and miRNAs in human cancer.人类癌症中的表观遗传学和 miRNA。
Adv Genet. 2010;70:87-99. doi: 10.1016/B978-0-12-380866-0.60004-6.
10
Targeting aberrant chromatin structure in colorectal carcinomas.针对结直肠癌中异常的染色质结构
Cancer J. 2007 Jan-Feb;13(1):49-55. doi: 10.1097/PPO.0b013e31803c72fe.
引用本文的文献
1
Comprehensive multimodal and multiomic profiling reveals epigenetic and transcriptional reprogramming in lung tumors.综合多模态和多组学分析揭示了肺肿瘤中的表观遗传和转录重编程。
Commun Biol. 2025 Mar 31;8(1):527. doi: 10.1038/s42003-025-07954-8.
2
Extracellular Matrix Cues Regulate Mechanosensing and Mechanotransduction of Cancer Cells.细胞外基质线索调节癌细胞的机械感知和机械转导。
Cells. 2024 Jan 2;13(1):96. doi: 10.3390/cells13010096.
3
Optical Imaging of Epigenetic Modifications in Cancer: A Systematic Review.癌症中表观遗传修饰的光学成像：一项系统综述。
Phenomics. 2022 Feb 7;2(2):88-101. doi: 10.1007/s43657-021-00041-y. eCollection 2022 Apr.
4
Computing microRNA-gene interaction networks in pan-cancer using miRDriver.利用 miRDriver 计算泛癌中的 microRNA-基因互作网络。
Sci Rep. 2022 Mar 8;12(1):3717. doi: 10.1038/s41598-022-07628-z.
5
The consequences of differential origin licensing dynamics in distinct chromatin environments.不同染色质环境中差异起源许可动力学的后果。
Nucleic Acids Res. 2022 Sep 23;50(17):9601-9620. doi: 10.1093/nar/gkac003.
6
Viral Manipulation of the Host Epigenome as a Driver of Virus-Induced Oncogenesis.病毒对宿主表观基因组的操控作为病毒诱导肿瘤发生的驱动因素
Microorganisms. 2021 May 30;9(6):1179. doi: 10.3390/microorganisms9061179.
7
Integrative pan cancer analysis reveals epigenomic variation in cancer type and cell specific chromatin domains.整合泛癌症分析揭示了癌症类型和细胞特异性染色质结构域中的表观基因组变化。
Nat Commun. 2021 Mar 3;12(1):1419. doi: 10.1038/s41467-021-21707-1.
8
Optimized Stochastic Optical Reconstruction Microscopy for Imaging Chromatin Structure in Pathological Tissue.优化的随机光学重建显微镜用于病理性组织中染色质结构成像。
Curr Protoc Cytom. 2020 Sep;94(1):e78. doi: 10.1002/cpcy.78.
9
Super-resolution imaging reveals the evolution of higher-order chromatin folding in early carcinogenesis.超分辨率成像揭示了早期癌变中高级染色质折叠的演变。
Nat Commun. 2020 Apr 20;11(1):1899. doi: 10.1038/s41467-020-15718-7.
10
3D-structured illumination microscopy reveals clustered DNA double-strand break formation in widespread γH2AX foci after high LET heavy-ion particle radiation.三维结构光照显微镜揭示了高传能线密度重离子粒子辐射后，广泛的γH2AX病灶中存在聚集的DNA双链断裂形成。
Oncotarget. 2017 Nov 25;8(65):109370-109381. doi: 10.18632/oncotarget.22679. eCollection 2017 Dec 12.
本文引用的文献
1
The cancer epigenome--components and functional correlates.癌症表观基因组——组成部分及其功能关联
Genes Dev. 2006 Dec 1;20(23):3215-31. doi: 10.1101/gad.1464906.
2
Polycomb silencers control cell fate, development and cancer.多梳抑制因子控制细胞命运、发育和癌症。
Nat Rev Cancer. 2006 Nov;6(11):846-56. doi: 10.1038/nrc1991.
3
Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing.在衰老过程中，p16INK4a表达增加会减少前脑祖细胞和神经发生。
Nature. 2006 Sep 28;443(7110):448-52. doi: 10.1038/nature05091. Epub 2006 Sep 6.
4
p16INK4a induces an age-dependent decline in islet regenerative potential.p16INK4a诱导胰岛再生潜能出现年龄依赖性下降。
Nature. 2006 Sep 28;443(7110):453-7. doi: 10.1038/nature05092. Epub 2006 Sep 6.
5
Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a.细胞周期蛋白依赖性激酶抑制剂p16INK4a修饰的干细胞衰老
Nature. 2006 Sep 28;443(7110):421-6. doi: 10.1038/nature05159. Epub 2006 Sep 6.
6
Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms.联合DNA甲基转移酶和组蛋白脱乙酰酶抑制用于治疗髓系肿瘤
Cancer Res. 2006 Jun 15;66(12):6361-9. doi: 10.1158/0008-5472.CAN-06-0080.
7
Tumor suppressor p16INK4A regulates polycomb-mediated DNA hypermethylation in human mammary epithelial cells.肿瘤抑制因子p16INK4A在人乳腺上皮细胞中调节多梳蛋白介导的DNA高甲基化。
J Biol Chem. 2006 Aug 25;281(34):24790-802. doi: 10.1074/jbc.M604175200. Epub 2006 Jun 9.
8
Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation.沉默信息调节因子1（SIRT1）的抑制可重新激活沉默的癌症基因，而不会导致启动子DNA高甲基化的丧失。
PLoS Genet. 2006 Mar;2(3):e40. doi: 10.1371/journal.pgen.0020040. Epub 2006 Mar 31.
9
Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromatic chromatin state.通过DNA去甲基化重新激活的沉默肿瘤抑制基因不会恢复到完全常染色质状态。
Cancer Res. 2006 Apr 1;66(7):3541-9. doi: 10.1158/0008-5472.CAN-05-2481.
10
Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction?癌症中的表观遗传基因沉默——早期致癌途径成瘾的一种机制？
Nat Rev Cancer. 2006 Feb;6(2):107-16. doi: 10.1038/nrc1799.
Zotero 插件