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超临界二氧化碳：为生物材料注入活力。

Supercritical carbon dioxide: putting the fizz into biomaterials.

作者信息

Barry John J A, Silva Marta M C G, Popov Vladimir K, Shakesheff Kevin M, Howdle Steven M

机构信息

Tissue Engineering Group, School of Pharmacy, The University of Nottingham, University Park, Nottingham NG7 2RD, UK.

出版信息

Philos Trans A Math Phys Eng Sci. 2006 Jan 15;364(1838):249-61. doi: 10.1098/rsta.2005.1687.

DOI:10.1098/rsta.2005.1687
PMID:17464360
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1855442/
Abstract

This paper describes recent progress made in the use of high pressure or supercritical fluids to process polymers into three-dimensional tissue engineering scaffolds. Three current examples are highlighted: foaming of acrylates for use in cartilage tissue engineering; plasticization and encapsulation of bioactive species into biodegradable polyesters for bone tissue engineering; and a novel laser sintering process used to fabricate three-dimensional biodegradable polyester structures from particles prepared via a supercritical route.

摘要

本文描述了在利用高压或超临界流体将聚合物加工成三维组织工程支架方面取得的最新进展。重点介绍了三个当前的例子：用于软骨组织工程的丙烯酸酯发泡；将生物活性物质增塑并封装到用于骨组织工程的可生物降解聚酯中；以及一种新颖的激光烧结工艺，该工艺用于由通过超临界途径制备的颗粒制造三维可生物降解聚酯结构。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c621/2696083/f2585b0e70cc/rsta20051687f07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c621/2696083/fa06eb90a4b0/rsta20051687f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c621/2696083/d69afa879ed3/rsta20051687f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c621/2696083/2887ab93c997/rsta20051687f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c621/2696083/c12395a0a92c/rsta20051687f04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c621/2696083/80612bb575e7/rsta20051687f05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c621/2696083/38f4fb5586e9/rsta20051687f06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c621/2696083/f2585b0e70cc/rsta20051687f07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c621/2696083/fa06eb90a4b0/rsta20051687f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c621/2696083/d69afa879ed3/rsta20051687f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c621/2696083/2887ab93c997/rsta20051687f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c621/2696083/c12395a0a92c/rsta20051687f04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c621/2696083/80612bb575e7/rsta20051687f05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c621/2696083/38f4fb5586e9/rsta20051687f06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c621/2696083/f2585b0e70cc/rsta20051687f07.jpg

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Interactions of chondrocytes with methacrylate copolymers.软骨细胞与甲基丙烯酸酯共聚物的相互作用。
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