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为化学注入活力:超临界二氧化碳在组织工程、药物递送及新型嵌段共聚物合成中的应用

Putting the fizz into chemistry: applications of supercritical carbon dioxide in tissue engineering, drug delivery and synthesis of novel block copolymers.

作者信息

Tai H, Popov V K, Shakesheff K M, Howdle S M

机构信息

Clean Technology Group, School of Chemistry, University of Nottingham, University Park, Nottingham NG 7 2RD, UK.

出版信息

Biochem Soc Trans. 2007 Jun;35(Pt 3):516-21. doi: 10.1042/BST0350516.

Abstract

This paper describes the recent progress at Nottingham towards the exploitation of the unique properties of scCO(2) (supercritical carbon dioxide) for the preparation of polymeric scaffolds for tissue engineering applications and new devices for controlled drug delivery, as well as the synthesis of novel block copolymers by the combination of eROP (enzymatic ring opening polymerization) and controlled polymerization methods for the potential use as drug carriers.

摘要

本文介绍了诺丁汉大学近期在利用超临界二氧化碳(scCO₂)的独特性质制备用于组织工程应用的聚合物支架和新型控释给药装置方面所取得的进展,以及通过酶促开环聚合(eROP)与可控聚合方法相结合合成新型嵌段共聚物以用作潜在药物载体的相关进展。

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