Spitzer Carsten, Vogel Matthias, Barnow Sven, Freyberger Harald J, Grabe Hans Joergen
Department of Psychiatry and Psychotherapy, Ernst-Moritz-Arndt University, Rostocker Chaussee 70, 18437 Stralsund, Germany.
Eur Arch Psychiatry Clin Neurosci. 2007 Jun;257(4):191-6. doi: 10.1007/s00406-006-0669-z.
To empirically investigate whether or not symptoms of posttraumatic stress disorder (PTSD) are essential for transferring the negative effects of trauma on the severity of severe mental illness (SMI) as recently suggested by an interactive model.
About 122 inpatients with either schizophrenia or major affective disorder were administered the Posttraumatic Diagnostic Scale, the Symptom Checklist and the Toronto Alexithymia Scale.
At least one trauma was reported by 83 participants (68%) and 28 patients (23%) reported symptoms of current PTSD. Those SMI subjects with current PTSD symptoms had significantly more psychopathological distress and alexithymic features than those with a trauma exposure but without PTSD symptoms and those patients without any traumatic experiences.
In line with prior research, our data indicate that patients with SMI have frequently been exposed to traumatic events and that a third suffers from current posttraumatic stress symptoms. Despite some methodological limitations our findings support the interactive model, which posits that a comorbid PTSD increases the symptom severity of SMI. More attention should be directed at assessing trauma and PTSD in SMI patients and at developing therapeutic interventions.
根据最近一个交互模型所提出的观点，通过实证研究创伤后应激障碍（PTSD）症状对于将创伤的负面影响转移至严重精神疾病（SMI）严重程度方面是否至关重要。
对约122名患有精神分裂症或重度情感障碍的住院患者进行创伤后诊断量表、症状清单和多伦多述情障碍量表的评估。
83名参与者（68%）报告至少经历过一次创伤，28名患者（23%）报告有当前PTSD症状。那些有当前PTSD症状的SMI受试者比那些有创伤暴露但无PTSD症状的受试者以及那些没有任何创伤经历的患者有明显更多的精神病理困扰和述情障碍特征。
与先前的研究一致，我们的数据表明，SMI患者经常暴露于创伤事件，并且三分之一的患者患有当前的创伤后应激症状。尽管存在一些方法学上的局限性，但我们的研究结果支持交互模型，该模型认为共病的PTSD会增加SMI的症状严重程度。应该更加关注评估SMI患者的创伤和PTSD，并开发治疗干预措施。
