Godeiro Katyanne D, Coutinho Anamaria B, Pereira Patricia R, Fernandes Bruno F, Cassie Amanda, Burnier Miguel N
Department of Ophthalmology & Pathology, Henry C. Witelson Ocular Pathology Laboratory, Montreal, Canada.
Ophthalmic Epidemiol. 2007 Mar-Apr;14(2):70-5. doi: 10.1080/09286580600954330.
To determine the most common histopathological diagnosis of corneal specimens from penetrating keratoplasty (PKP).
The records of 500 corneal specimens submitted to biopsy at the Henry Witelson Ocular Pathology Laboratory, Montreal, Canada, from 1999 to 2004 were reviewed. Age, sex, clinical indications, and histopathological findings were analyzed.
Chronic keratitis (45.6%) was the most common pathological diagnosis, followed by corneal edema (25.8%), dystrophy (12.8%), keratoconus (KC) (9.2%), acute keratitis (5.6%), and degeneration (1.0%). Among the specimens with chronic keratitis, regraft was the most common clinical indication (39.0%). In the group of acute keratitis, ulcerative condition was the leading cause (75,0%). Fuchs' endothelial dystrophy represented 79.7% of the clinical diagnoses in the group of corneal dystrophies. The median patient age was 70-79 years, and the gender distribution was nearly symmetric.
The present study is important for determining the most common histopathological diagnoses of corneal button specimens and the correlation with the age, gender, and clinical indications of PKP.
确定穿透性角膜移植术（PKP）角膜标本最常见的组织病理学诊断。
回顾了1999年至2004年提交至加拿大蒙特利尔亨利·维特尔森眼病理实验室进行活检的500份角膜标本记录。分析了年龄、性别、临床指征和组织病理学结果。
慢性角膜炎（45.6%）是最常见的病理诊断，其次是角膜水肿（25.8%）、营养不良（12.8%）、圆锥角膜（KC）（9.2%）、急性角膜炎（5.6%）和变性（1.0%）。在慢性角膜炎标本中，再次移植是最常见的临床指征（39.0%）。在急性角膜炎组中，溃疡状态是主要原因（75.0%）。富克斯内皮营养不良占角膜营养不良组临床诊断的79.7%。患者年龄中位数为70 - 79岁，性别分布几乎对称。
本研究对于确定角膜植片标本最常见的组织病理学诊断以及与PKP患者年龄、性别和临床指征的相关性具有重要意义。
