Li Xiaohua, Wang Liya, Dustin Laurie, Wei Qiucai
Henan Eye Hospital, Zhengzhou, China.
Invest Ophthalmol Vis Sci. 2014 May 8;55(5):3022-8. doi: 10.1167/iovs.13-13805.
To analyze the age distribution of corneal disease in China by histopathological examination.
A retrospective histopathological analysis of the prevalence and age distribution of corneal disease was performed on corneal specimens from 3112 patients who underwent corneal surgery between 2001 and 2012 in the Henan Eye Institute.
Infectious keratitis (2212 specimens, 71.08%) was the most common corneal disease. The distribution of age groups was significantly higher after age 30 (16.29%), reaching a peak by age 40 (22.04%) and remaining high until age 59 (21.05%, P < 0.01). The highest age-specific percentage of corneal infection was between the ages of 50 and 59 (83.21%, P < 0.01). Noninfectious corneal diseases occurred mainly in the age range of 10 to 19 years (42.47%) and 20 to 29 years (40.78%). Between the ages of 10 and 19, the leading pathologic diagnosis was keratoconus, accounting for 21.29% of cases. In patients aged 80 and older, the most common noninfectious corneal diseases were Terrien-marginal degeneration (8.33%) and Mooren's ulcer (4.17%). The highest incidence of corneal tumor was seen between the ages of 0 and 9 years (65.83%) and age 80 and older (45.86%; P < 0.01).
The age distribution of corneal diseases in the Chinese population is distinct from other countries. The corneal diseases tend to increase in prevalence in middle age, especially for infectious corneal disease. The prevalence of corneal tumor is high in early and late life. Corneal degenerative disease occurs predominately in seniors.
通过组织病理学检查分析中国角膜疾病的年龄分布情况。
对2001年至2012年在河南省眼科研究所接受角膜手术的3112例患者的角膜标本进行角膜疾病患病率及年龄分布的回顾性组织病理学分析。
感染性角膜炎（2212例标本，71.08%）是最常见的角膜疾病。30岁以后各年龄组的分布显著升高（16.29%），40岁达到峰值（22.04%），并一直保持高位直至59岁（21.05%，P<0.01）。角膜感染的最高年龄特异性百分比出现在50至59岁之间（83.21%，P<0.01）。非感染性角膜疾病主要发生在10至19岁（42.47%）和20至29岁（40.78%）年龄段。在10至19岁之间，主要的病理诊断是圆锥角膜，占病例的21.29%。在80岁及以上的患者中，最常见的非感染性角膜疾病是Terrien边缘变性（8.33%）和蚕蚀性角膜溃疡（4.17%）。角膜肿瘤的最高发病率出现在0至9岁之间（65.83%）和80岁及以上（45.86%；P<0.01）。
中国人群角膜疾病的年龄分布与其他国家不同。角膜疾病的患病率在中年时往往会增加，尤其是感染性角膜疾病。角膜肿瘤在生命早期和晚期的患病率较高。角膜退行性疾病主要发生在老年人中。
