Tenjarla G, Kumar A, Dyke J W
Department of Pediatrics and Human Development, Michigan State University, East Lansing 48824-1317.
Am J Clin Pathol. 1991 Dec;96(6):759-61. doi: 10.1093/ajcp/96.6.759.
Results obtained with Abbott Laboratories' TestPack Strep A, a rapid test kit to detect group A streptococcal antigen on throat swabs, were compared with the culture results. All tests were performed by American Society of Clinical Pathology-registered technologists in a large clinical laboratory. A total of 11,088 throat swabs were tested; 9,161 belonged to pediatric patients and 1,927 to adults. For TestPack Strep A, the study demonstrated a sensitivity value of 0.91 and a specificity value of 0.96; positive predictive value and negative predictive values were 0.82 and 0.98, respectively. These data indicate that even when performed by experienced technologists, in a laboratory setting, approximately 1 of 10 patients with group A streptococcal tonsillopharyngitis will be missed if physicians rely solely on this direct antigen test. A backup culture on all patients who are negative by a rapid antigen detection test is recommended.
将雅培实验室的A群链球菌快速检测试剂盒（一种用于检测咽拭子上A群链球菌抗原的快速检测试剂盒）所获得的结果与培养结果进行了比较。所有检测均由美国临床病理学会注册技术人员在一家大型临床实验室进行。总共对11,088份咽拭子进行了检测；其中9,161份属于儿科患者，1,927份属于成人。对于A群链球菌快速检测试剂盒，该研究显示其灵敏度值为0.91，特异性值为0.96；阳性预测值和阴性预测值分别为0.82和0.98。这些数据表明，即使在实验室环境中由经验丰富的技术人员进行操作，如果医生仅依赖这种直接抗原检测，每10例A群链球菌性扁桃体咽炎患者中仍约有1例会被漏诊。建议对所有快速抗原检测呈阴性的患者进行后备培养。
