原肌球蛋白作为交叉反应性变应原在马提尼克岛（法属加勒比岛屿）对螨有呼吸道过敏且对蟹和虾有食物过敏的患者对蟑螂致敏中的作用。
Role of tropomyosin as a cross-reacting allergen in sensitization to cockroach in patients from Martinique (French Caribbean island) with a respiratory allergy to mite and a food allergy to crab and shrimp.
作者信息
Purohit A, Shao J, Degreef J M, van Leeuwen A, van Ree R, Pauli G, de Blay F
机构信息
Division of Asthma and Allergy, Department of Chest Diseases, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
出版信息
Eur Ann Allergy Clin Immunol. 2007 Mar;39(3):85-8.
BACKGROUND
Tropomyosin has been described as cross-reacting allergen between mite, cockroach and shrimp.
METHODS
In 13 patients with asthma and/or rhinitis sensitized to mite and/or German cockroach and presenting urticaria, oral allergy syndrome or angio-edema upon eating shrimp and/or crab, we measured specific IgE to mite, cockroach, crab and shrimp tropomyosin.
RESULTS
Ten patients had specific IgE to tropomyosin from mite, 8 from shrimp, 6 from crab and 5 from cockroach. AST inhibition tests indicated that mite allergen is a primary sensitizer and is cross-reacting with shrimp, crab and cockroach allergens.
CONCLUSION
Tropomyosin could be the cross-reacting allergen relevant for clinical symptoms to mite, cockroach, shrimp and crab.
背景
原肌球蛋白已被描述为螨虫、蟑螂和虾之间的交叉反应性变应原。
方法
在13例对螨虫和/或德国蟑螂致敏且患有哮喘和/或鼻炎的患者中，这些患者在食用虾和/或蟹后出现荨麻疹、口腔过敏综合征或血管性水肿，我们检测了他们对螨虫、蟑螂、蟹和虾原肌球蛋白的特异性IgE。
结果
10例患者对螨虫原肌球蛋白有特异性IgE，8例对虾原肌球蛋白有特异性IgE，6例对蟹原肌球蛋白有特异性IgE，5例对蟑螂原肌球蛋白有特异性IgE。AST抑制试验表明，螨虫变应原是主要致敏原，且与虾、蟹和蟑螂变应原发生交叉反应。
结论
原肌球蛋白可能是与对螨虫、蟑螂、虾和蟹的临床症状相关的交叉反应性变应原。
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