Purohit A, Shao J, Degreef J M, van Leeuwen A, van Ree R, Pauli G, de Blay F
Division of Asthma and Allergy, Department of Chest Diseases, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
Eur Ann Allergy Clin Immunol. 2007 Mar;39(3):85-8.
Tropomyosin has been described as cross-reacting allergen between mite, cockroach and shrimp.
In 13 patients with asthma and/or rhinitis sensitized to mite and/or German cockroach and presenting urticaria, oral allergy syndrome or angio-edema upon eating shrimp and/or crab, we measured specific IgE to mite, cockroach, crab and shrimp tropomyosin.
Ten patients had specific IgE to tropomyosin from mite, 8 from shrimp, 6 from crab and 5 from cockroach. AST inhibition tests indicated that mite allergen is a primary sensitizer and is cross-reacting with shrimp, crab and cockroach allergens.
Tropomyosin could be the cross-reacting allergen relevant for clinical symptoms to mite, cockroach, shrimp and crab.
原肌球蛋白已被描述为螨虫、蟑螂和虾之间的交叉反应性变应原。
在13例对螨虫和/或德国蟑螂致敏且患有哮喘和/或鼻炎的患者中，这些患者在食用虾和/或蟹后出现荨麻疹、口腔过敏综合征或血管性水肿，我们检测了他们对螨虫、蟑螂、蟹和虾原肌球蛋白的特异性IgE。
10例患者对螨虫原肌球蛋白有特异性IgE，8例对虾原肌球蛋白有特异性IgE，6例对蟹原肌球蛋白有特异性IgE，5例对蟑螂原肌球蛋白有特异性IgE。AST抑制试验表明，螨虫变应原是主要致敏原，且与虾、蟹和蟑螂变应原发生交叉反应。
原肌球蛋白可能是与对螨虫、蟑螂、虾和蟹的临床症状相关的交叉反应性变应原。
