Chew G L, Reardon A M, Correa J C, Young M, Acosta L, Mellins R, Chew F T, Perzanowski M S
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
Indoor Air. 2009 Jun;19(3):193-7. doi: 10.1111/j.1600-0668.2008.00578.x. Epub 2009 Feb 7.
In New York (NY), Latinos often have greater asthma morbidity than other ethnicities, and dust-mite sensitization is common despite low allergen levels. We investigated mite allergen exposure and sensitization in atopic and/or asthmatic women, the majority being Puerto Rican. Women (n = 274) recruited for a birth cohort study were visited postnatally. Dust from their homes was analyzed for mite allergens (Der f 1, Der p 1, and Blo t 5). Serum was analyzed for total and allergen-specific IgE. Thirty-seven percent were sensitized to Dermatophagoides pteronyssinus, 34% to Dermatophagoides farinae, and 21% to Blomia tropicalis. Only 5% of NY homes had levels of Der f 1 >2 microg/g; none had Blo t 5 or Der p 1 above this level. Caribbean or Latin American birthplace (a proxy for childhood exposure) was not associated with mite sensitization. Sensitization to D. pteronyssinus and D. farinae was associated with a report of doctor-diagnosed asthma [Odds ratio (OR) = 3.27, P = 0.003; OR = 2.81, P = 0.010, respectively]; sensitization to any mite was associated with asthma medication use in the past 12 months (OR = 3.12, P = 0.004). These associations held even after adjustment for cockroach, mouse, and cat sensitization.
Despite the low concentrations of mite allergen in our community, many of the women in the atopically enriched cohort were sensitized to mites, even Blomia tropicalis which is typically found only in tropical environments.
在纽约（NY），拉丁裔人群的哮喘发病率通常高于其他种族，尽管过敏原水平较低，但尘螨致敏现象却很常见。我们调查了特应性和/或哮喘女性中的螨过敏原暴露和致敏情况，其中大多数为波多黎各裔。招募参加一项出生队列研究的女性（n = 274）在产后接受了访视。对她们家中的灰尘进行螨过敏原（Der f 1、Der p 1和Blo t 5）分析。对血清进行总IgE和过敏原特异性IgE分析。37%的人对屋尘螨致敏，34%对粉尘螨致敏，21%对热带无爪螨致敏。纽约只有5%的家庭Der f 1水平>2微克/克；没有家庭的Blo t 5或Der p 1高于此水平。加勒比或拉丁美洲出生地（童年暴露的一个指标）与螨致敏无关。对屋尘螨和粉尘螨的致敏与医生诊断的哮喘报告相关[比值比（OR）= 3.27，P = 0.003；OR = 2.81，P = 0.010，分别]；对任何螨的致敏与过去12个月内使用哮喘药物相关（OR = 3.12，P = 0.004）。即使在对蟑螂、小鼠和猫致敏进行校正后，这些关联仍然成立。
尽管我们社区中螨过敏原浓度较低，但在这个特应性丰富的队列中的许多女性对螨致敏，甚至对通常仅在热带环境中发现的热带无爪螨也致敏。
