MAST-CLA结果作为过敏性皮肤病诊断工具的分析

Analysis of MAST-CLA Results as a Diagnostic Tool in Allergic Skin Diseases.

作者信息

Shin Jung Won, Jin Seon-Pil, Lee Jong Hee, Cho Soyun

机构信息

Department of Dermatology, Seoul National University College of Medicine, Boramae Hospital, Seoul, Korea.

出版信息

Ann Dermatol. 2010 Feb;22(1):35-40. doi: 10.5021/ad.2010.22.1.35. Epub 2010 Feb 28.

DOI:10.5021/ad.2010.22.1.35

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2883394/

Abstract

BACKGROUND

Urticaria and atopic dermatitis are representative allergic skin diseases that can be mediated by IgE. Measuring levels of specific IgE can be used to confirm causative agents of these skin diseases.

OBJECTIVE

To analyze results from the multiple allergosorbent test chemiluminescent assay (MAST-CLA), which measures specific IgE in the presence of a causative agent/allergen, in IgE-mediated skin diseases.

METHODS

A total of 404 patients with urticaria, atopic dermatitis or pruritus were enrolled in the present study. Positive rates of specific IgE as well as total serum IgE from the MAST-CLA were compared.

RESULTS

Positive rates of specific IgE were highest in atopic dermatitis patients, followed by urticaria, and then pruritus, with 57.0%, 37.1%, and 20.8%, respectively (p<0.05). House dust mite species were the most common allergens in both atopic dermatitis and urticaria skin diseases. There were no differences in the overall MAST-CLA results between acute and chronic urticaria. The relative positive rate of inhalant allergen was significantly higher in adult than in child atopic dermatitis patients.

CONCLUSION

Results from the MAST-CLA showed diversity among the three disease groups, and within each disease group, with different positive rates of specific IgE, a different mean allergen number per patient, and so on. Therefore, we concluded that MAST-CLA could be a useful diagnostic tool for various allergic skin diseases.

摘要

背景

荨麻疹和特应性皮炎是可由IgE介导的典型过敏性皮肤病。检测特异性IgE水平可用于确定这些皮肤病的致病因素。

目的

分析在IgE介导的皮肤病中，用于检测在致病因素/过敏原存在下特异性IgE的多过敏原吸附试验化学发光法（MAST-CLA）的结果。

方法

本研究共纳入404例荨麻疹、特应性皮炎或瘙痒症患者。比较MAST-CLA检测的特异性IgE阳性率以及总血清IgE水平。

结果

特异性IgE阳性率在特应性皮炎患者中最高，其次是荨麻疹，然后是瘙痒症，分别为57.0%、37.1%和20.8%（p<0.05）。屋尘螨是特应性皮炎和荨麻疹皮肤病中最常见的过敏原。急性和慢性荨麻疹患者的MAST-CLA总体结果无差异。在成年特应性皮炎患者中，吸入性过敏原的相对阳性率显著高于儿童患者。

结论

MAST-CLA的结果在三个疾病组之间以及每个疾病组内部均表现出多样性，特异性IgE阳性率不同、每位患者的平均过敏原数量不同等。因此，我们得出结论，MAST-CLA可能是用于各种过敏性皮肤病的有用诊断工具。