Housa D, Vernerová Z, Heráček J, Procházka B, Čechák P, Kuncová J, Haluzík M
Third Department of Internal Medicine, First Faculty of Medicine and General Faculty Hospital Prague, U nemocnice 2, Prague, Czech Republic.
Physiol Res. 2008;57(3):451-458. doi: 10.33549/physiolres.931156. Epub 2007 Apr 25.
Serum levels of adiponectin were measured in patients with benign prostatic hyperplasia and prostate cancer of pT2 and pT3 stage. Adiponectin ELISA assay, immunohistochemistry, and selected metabolic and biochemical parameters measurement was performed in 25 patients with benign prostatic hyperplasia and 43 with prostate cancer (17 patients with organ-confined and 26 patients with locally advanced disease). Serum adiponectin levels did not differ between prostate benign hyperplasia and cancer clinical stage T2, but was significantly higher in pT3 relative to pT2 group (14.51+/-4.92 vs. 21.41+/-8.12, P = 0.003). Tissue immunohistochemistry showed enhanced staining in neoplastic prostate glands and intraepithelial neoplasia relative to benign prostatic hyperplasia without distinction between disease grade and stage. Serum adiponectin levels are higher in locally advanced relative to organ-confined prostate cancer and may thus serve as an auxiliary marker providing further improvement for discrimination between pT2 and pT3 stages.
在患有良性前列腺增生以及处于pT2和pT3期前列腺癌的患者中测量了血清脂联素水平。对25例良性前列腺增生患者和43例前列腺癌患者（17例器官局限性疾病患者和26例局部晚期疾病患者）进行了脂联素酶联免疫吸附测定、免疫组织化学以及选定的代谢和生化参数测量。前列腺良性增生与癌症临床T2期之间的血清脂联素水平无差异，但pT3组相对于pT2组显著更高（14.51±4.92对21.41±8.12，P = 0.003）。组织免疫组织化学显示，相对于良性前列腺增生，肿瘤性前列腺腺体和上皮内瘤变中的染色增强，且疾病分级和分期之间无差异。局部晚期前列腺癌相对于器官局限性前列腺癌的血清脂联素水平更高，因此可作为一种辅助标志物，为区分pT2和pT3期提供进一步的鉴别依据。
