Mather Melissa L, Morgan Stephen P, Crowe John A
Applied Optics Group, School of Electrical and Electronic Engineering, University of Nottingham, Nottingham, UK.
Regen Med. 2007 Mar;2(2):145-60. doi: 10.2217/17460751.2.2.145.
Tissue engineering is a rapidly growing field that aims to develop biological substitutes that restore, maintain or improve tissue function. The focus of research to date has been the underlying biology required for tissue-engineered therapies. However, as tissue-engineered products reach the marketplace, there is a pressing need for an improved understanding of the engineering and economic issues associated with them. This is motivated by the lack of commercial viability of many of the initial therapies that have been produced. It has been suggested in the literature that this is partly due to poor process and system design in tissue production, as well as a lack of process monitoring and control. This review argues that principles of design, measurement and process monitoring from the physical sciences are needed to move tissue engineering forward, and that much of the technology needed to realize this is already available.
组织工程是一个快速发展的领域，旨在开发能够恢复、维持或改善组织功能的生物替代品。迄今为止，研究重点一直是组织工程疗法所需的基础生物学。然而，随着组织工程产品进入市场，迫切需要更好地理解与之相关的工程和经济问题。这是由于许多最初生产的疗法缺乏商业可行性所推动的。文献中指出，这部分是由于组织生产过程和系统设计不佳，以及缺乏过程监测和控制。本综述认为，需要物理科学中的设计、测量和过程监测原则来推动组织工程向前发展，而且实现这一目标所需的许多技术已经存在。
