远距离DNA相互作用：细胞核中的浪漫故事？

Long-range DNA contacts: romance in the nucleus?

作者信息

de Laat Wouter

机构信息

Department of Cell Biology, Erasmus MC, Dr. Molewaterplein 50, 3015 GE Rotterdam, The Netherlands.

出版信息

Curr Opin Cell Biol. 2007 Jun;19(3):317-20. doi: 10.1016/j.ceb.2007.04.004. Epub 2007 Apr 27.

DOI:10.1016/j.ceb.2007.04.004

PMID:17467258

Abstract

Recent studies show that genes far apart on the same chromosome or even on different chromosomes can come together in the nuclear space. It has been hypothesized that functionally related genes 'kiss' at transcription factories to coordinate their expression. Novel high-throughput methods, such as 4C technology, that study DNA interactions in an unbiased manner should uncover the generality of this romantic concept of nuclear architecture.

摘要

最近的研究表明，位于同一条染色体上甚至不同染色体上距离较远的基因能够在核空间中聚集在一起。据推测，功能相关的基因在转录工厂中“亲吻”以协调它们的表达。诸如4C技术等新型高通量方法能够以无偏差的方式研究DNA相互作用，应该会揭示这种关于核结构的浪漫概念的普遍性。