胸腺切除术后AKR小鼠白血病病毒的表达
Murine leukaemia virus expression in the AKR following thymectomy.
作者信息
Tuffrey M, Crewe P, Dawson L, Holliday J, Barnes R D
出版信息
Br J Cancer. 1975 Oct;32(4):465-70. doi: 10.1038/bjc.1975.248.
Abstract
Thymectomy effectively prevents the development of spontaneous lymphoma in the AKR but how this effect is achieved remains to be determined. One possible mechanism, namely suppression of genomic expression of the oncogenic murine leukaemia virus now seems unlikely since levels of the group specific MuLV antigen were in comparision with their sham operated controls unaltered in both neonatally and adult thymectomized AKR.
摘要
胸腺切除术可有效预防AKR小鼠自发性淋巴瘤的发生，但这种效果是如何实现的仍有待确定。一种可能的机制，即抑制致癌性鼠白血病病毒的基因组表达，现在看来不太可能，因为与假手术对照组相比，新生和成年胸腺切除的AKR小鼠中，组特异性MuLV抗原水平均未改变。
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本文引用的文献
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Suppression of lymphoma development in tetraparental AKR mouse chimaeras derived from ovum fusion.源自卵融合的四亲代AKR小鼠嵌合体中淋巴瘤发展的抑制
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Murine leukemia virus group-specific antigen expression in AKR mice.AKR小鼠中鼠白血病病毒群特异性抗原的表达
Cancer Res. 1974 Oct;34(10):2553-61.
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