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携带blaIMP-1和新氨基糖苷类耐药基因aac(6')-31的整合子的特征分析及其在巴西一家医院基因不相关临床分离株中的传播情况。

Characterization of an integron carrying blaIMP-1 and a new aminoglycoside resistance gene, aac(6')-31, and its dissemination among genetically unrelated clinical isolates in a Brazilian hospital.

作者信息

Mendes Rodrigo E, Castanheira Mariana, Toleman Mark A, Sader Helio S, Jones Ronald N, Walsh Timothy R

机构信息

Laboratório Especial de Microbiologia Clínica and Laboratório ALERTA, Division of Infectious Disease, Federal University of São Paulo, São Paulo, Brazil.

出版信息

Antimicrob Agents Chemother. 2007 Jul;51(7):2611-4. doi: 10.1128/AAC.00838-06. Epub 2007 Apr 30.

DOI:10.1128/AAC.00838-06
PMID:17470660
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1913225/
Abstract

Seven bla(IMP-1)-harboring Acinetobacter sp. isolates and one Pseudomonas putida clinical isolate were recovered from hospitalized patients. All isolates possessed a class 1 integron, named In86, carrying the same cassette array [bla(IMP1), aac(6')-31, and aadA1], which was plasmid located in five of the isolates. This report describes the ability of nonfermentative nosocomial pathogens to acquire and disseminate antimicrobial resistance determinants.

摘要

从住院患者中分离出7株携带bla(IMP-1)的不动杆菌属菌株和1株恶臭假单胞菌临床分离株。所有分离株都含有一个名为In86的1类整合子，携带相同的盒式阵列[bla(IMP1)、aac(6')-31和aadA1]，其中5株分离株的该整合子位于质粒上。本报告描述了非发酵医院病原体获取和传播抗菌药物耐药决定簇的能力。

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