Bush K, Miller G H
RW Johnson Pharmaceutical Research Institute, 1000 Route 202, Raritan NJ 08869, USA.
Curr Opin Microbiol. 1998 Oct;1(5):509-15. doi: 10.1016/s1369-5274(98)80082-9.
Numerous novel beta-lactamases and aminoglycoside-modifying enzymes with altered substrate profiles continue to be identified. Plasmid-mediated transmission of many of these enzymes readily occurs due to inclusion of the encoding genes in mobile gene cassettes. Recent crystallographic determinations of the structures of metallo-beta-lactamases and aminoglycoside-modifying enzymes provide the opportunity for the rational design of inhibitors.
不断有新的具有改变底物谱的β-内酰胺酶和氨基糖苷类修饰酶被发现。由于编码基因存在于移动基因盒中，许多这类酶通过质粒介导的方式很容易发生传播。最近对金属β-内酰胺酶和氨基糖苷类修饰酶结构的晶体学测定为合理设计抑制剂提供了机会。
