Besio W, Chen T
Department of Biomedical Engineering, Louisiana Tech University, Ruston, LA, USA.
Physiol Meas. 2007 May;28(5):515-29. doi: 10.1088/0967-3334/28/5/006. Epub 2007 Apr 20.
The electrocardiogram (ECG) provides useful global temporal assessment of the cardiac activity, but has limited spatial capabilities. The Laplacian electrocardiogram (LECG), an improvement over the ECG, provides high spatiotemporal distributed information about cardiac electrical activation. We designed and developed LECG tripolar concentric ring electrode active sensors based on the finite element algorithm 'nine-point method' (NPM). The active sensors were used in an array of 6 by 12 (72) locations to record bipolar and tripolar LECG from the body surface over the anterolateral chest. Compared to bipolar LECG, tripolar LECG showed significantly higher spatial selectivity which may be helpful in inferring information about cardiac activations detected on the body surface. In this study the moment of activation (MOA), an indicator of a depolarization wave passing below the active sensors, was used to surmise possible timing information of the cardiac electrical activation below the active sensors' recording sites. The MOA on the body surface was used to generate isochronal maps that may some day be used by clinicians in diagnosing arrhythmias and assessing the efficacy of therapies.
心电图（ECG）能对心脏活动进行有用的整体时间评估，但空间分辨能力有限。拉普拉斯心电图（LECG）是对ECG的改进，能提供关于心脏电活动的高时空分布信息。我们基于有限元算法“九点法”（NPM）设计并开发了LECG三极同心环电极有源传感器。这些有源传感器被用于6×12（72）个位置的阵列中，以记录前外侧胸部体表的双极和三极LECG。与双极LECG相比，三极LECG显示出显著更高的空间选择性，这可能有助于推断体表检测到的心脏激活信息。在本研究中，激活时刻（MOA）作为去极化波通过有源传感器下方的一个指标，被用于推测有源传感器记录部位下方心脏电活动的可能时间信息。体表的MOA被用于生成等时图，未来某天临床医生可能会用它来诊断心律失常和评估治疗效果。
