Mertens J, Müller-Deile J
ENT Department, University of Kiel, Federal Republic of Germany.
Eur Arch Otorhinolaryngol. 1991;248(7):402-5. doi: 10.1007/BF01463563.
Fentanyl/diazepam anesthesia is an appropriate combination for surgical operations on the guinea pig, since it ensures definitive anesthesia and analgesia without respiratory depression. Comparative investigations with pentobarbital and urethane were carried out to check their applicability for electrocochleographic recordings. We found that fentanyl/diazepam combination anesthesia is more suitable for electrocochleographic investigations than pentobarbital. We were thereby able to prove that pentobarbital has an attenuating effect on electrocochleographic recordings in contrast to the findings reported in the available literature. For this reason, and because the lowest rates of animal morbidity occurred with fentanyl/diazepam, this combination anesthesia should be used preferentially for electrophysiological experiments in guinea pigs.
芬太尼/地西泮麻醉是豚鼠外科手术的合适组合，因为它能确保确切的麻醉和镇痛效果，且不会导致呼吸抑制。我们进行了与戊巴比妥和乌拉坦的对比研究，以检验它们在耳蜗电图记录中的适用性。我们发现，芬太尼/地西泮联合麻醉比戊巴比妥更适合用于耳蜗电图研究。由此我们得以证明，与现有文献报道的结果相反，戊巴比妥对耳蜗电图记录有衰减作用。因此，鉴于使用芬太尼/地西泮时动物发病率最低，这种联合麻醉应优先用于豚鼠的电生理实验。
