Danese Silvio, Dejana Elisabetta, Fiocchi Claudio
Instituto di Ricerca e Cura a Carattere Scientifico Istituto Clinico Humanitas, Milan, Italy.
J Immunol. 2007 May 15;178(10):6017-22. doi: 10.4049/jimmunol.178.10.6017.
An effective immune response depends not only on the proper activation, regulation, and function of immune cells, but also on their distribution and retention in diverse tissue microenvironments where they encounter a number of stimuli and other cell types. These activities are mediated by endothelial cells, which form specialized microcirculatory networks used by immune cells under both physiological and pathological circumstances. Endothelial cells represent a highly heterogeneous population of cells with the ability to interact with and modulate the function of immune cells. This review is focused on the role of microvascular endothelial cells in innate and adaptive immunity, inflammation, coagulation, angiogenesis, and the therapeutic implications of targeting endothelial cells in selected autoimmune and chronic inflammatory disorders.
有效的免疫反应不仅取决于免疫细胞的适当激活、调节和功能，还取决于它们在不同组织微环境中的分布和滞留情况，在这些微环境中它们会遇到多种刺激和其他细胞类型。这些活动由内皮细胞介导，内皮细胞形成了免疫细胞在生理和病理情况下都能使用的专门微循环网络。内皮细胞是一类高度异质性的细胞群体，具有与免疫细胞相互作用并调节其功能的能力。本综述聚焦于微血管内皮细胞在先天性和适应性免疫、炎症、凝血、血管生成中的作用，以及在特定自身免疫性和慢性炎症性疾病中靶向内皮细胞的治疗意义。
