用于在聚合物基底上快速原型制作无缝圆柱形微通道的简易制造技术。

Simple fabrication technique for rapid prototyping of seamless cylindrical microchannels in polymer substrates.

作者信息

Perry Hannah, Greiner Cherry, Georgakoudi Irene, Cronin-Golomb Mark, Omenetto Fiorenzo G

机构信息

Department of Biomedical Engineering, Science and Technology Center, Tufts University, Medford, MA 02155, USA.

出版信息

Rev Sci Instrum. 2007 Apr;78(4):044302. doi: 10.1063/1.2719626.

DOI:10.1063/1.2719626

PMID:17477682

Abstract

This article presents a simple and novel method for the fabrication of cylindrical microchannels in polymer or biopolymer substrates. This process results in highly regular, cylindrical microchannels, suitable both to the transport of liquid and the transmission of light. This method eliminates issues associated with positioning tolerances characteristic of conventional fabrication techniques, such as soft lithography. Such devices hold great promise in the field of biomedical engineering by providing a true cylindrical profile for microflow studies and vascular modeling, as well as the ability to optically analyze injected biological samples. An evaluation of these devices is performed by real time optical imaging of blood flow.

摘要

本文介绍了一种在聚合物或生物聚合物基底中制造圆柱形微通道的简单新颖方法。该工艺可形成高度规则的圆柱形微通道，适用于液体传输和光传输。这种方法消除了与传统制造技术（如软光刻）特有的定位公差相关的问题。此类装置通过为微流研究和血管建模提供真正的圆柱形轮廓，以及对注入的生物样品进行光学分析的能力，在生物医学工程领域具有巨大潜力。通过对血流的实时光学成像对这些装置进行评估。