Attia Rafaele, Pregibon Daniel C, Doyle Patrick S, Viovy Jean-Louis, Bartolo Denis
Laboratoire Physicochimie Curie, CNRS/UMR 168, 11 rue Pierre et Marie Curie, Paris, France.
Lab Chip. 2009 May 7;9(9):1213-8. doi: 10.1039/b813860e. Epub 2009 Feb 12.
We present a rapid prototyping method for integrating functional components in conventional PDMS microfluidic devices. We take advantage of stop-flow lithography (D. Dendukuri, S. S. Gu, D. C. Pregibon, T. A. Hatton and P. S. Doyle, Lab Chip, 2007, 7, 818)(1) to achieve the in situ fabrication of mobile and deformable elements with a controlled mechanical response. This strategy is applied to the fabrication of microflow sensors based on a deformable spring-like structure. We show that these sensors have a large dynamic range, typically 3 to 4 orders of magnitude, and that they can be scaled down to measure flows in the nl per min range. We prepared sensors with different geometries, and their flow-elongation characteristics were modeled with a simple hydrodynamic model, with good agreement between model and experiments.
我们提出了一种用于在传统聚二甲基硅氧烷（PDMS）微流控装置中集成功能组件的快速成型方法。我们利用停流光刻技术（D. Dendukuri、S. S. Gu、D. C. Pregibon、T. A. Hatton和P. S. Doyle，《芯片实验室》，2007年，第7卷，第818页）（1）来实现具有可控机械响应的可移动和可变形元件的原位制造。该策略应用于基于可变形弹簧状结构的微流传感器的制造。我们表明，这些传感器具有很大的动态范围，通常为3到4个数量级，并且可以缩小尺寸以测量每分钟纳升范围内的流量。我们制备了具有不同几何形状的传感器，并使用简单的流体动力学模型对其流动-伸长特性进行建模，模型与实验结果吻合良好。
