铁在某些临床感染中的关键作用。
The critical role of iron in some clinical infections.
作者信息
Bullen J J, Ward C G, Rogers H J
机构信息
Department of Surgery, University of Miami School of Medicine, Florida 33101.
出版信息
Eur J Clin Microbiol Infect Dis. 1991 Aug;10(8):613-7. doi: 10.1007/BF01975810.
The role of iron in certain clinical infections is revealed. In normal persons the antibacterial and antifungal properties of blood and other tissue fluids cannot be maintained unless there are exceptionally low levels of available iron. This is controlled by the presence of the unsaturated iron-binding proteins, transferrin and lactoferrin. In several clinical conditions an abnormal availability of iron is responsible for fatal septicaemia. This is because the phagocytic system is overwhelmed by rapidly growing organisms when iron is freely available.
铁在某些临床感染中的作用已被揭示。在正常人中，除非可利用铁的水平异常低，否则血液和其他组织液的抗菌和抗真菌特性无法维持。这由不饱和铁结合蛋白、转铁蛋白和乳铁蛋白的存在来控制。在几种临床情况下，铁的异常可用性会导致致命的败血症。这是因为当铁可自由获取时，吞噬系统会被快速生长的微生物 overwhelm。（这里“overwhelm”直译为“压倒、淹没”，结合语境可意译为“ overwhelm”，但原英文文本中该词拼写有误，正确拼写应为“overwhelmed”，意思是“使应接不暇、使难以承受” ），即吞噬系统会被快速生长的微生物搞得应接不暇。
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