瞬时受体电位（TRP）通道基因敲除小鼠失去了冷静。

TRP channel knockout mice lose their cool.

作者信息

Chung Man-Kyo, Caterina Michael J

机构信息

Department of Biological Chemistry, Center for Sensory Biology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.

出版信息

Neuron. 2007 May 3;54(3):345-7. doi: 10.1016/j.neuron.2007.04.025.

DOI:10.1016/j.neuron.2007.04.025

PMID:17481385

Abstract

Heat and cold transduction by peripheral sensory neurons is a fundamental step in the avoidance of dangerous thermal extremes. In this issue of Neuron, Dhaka et al. and Colburn et al. report that mice lacking the cold- and menthol-gated ion channel TRPM8 exhibit deficient behavioral responses to cold temperatures.

摘要

外周感觉神经元进行的热传导和冷传导是避免危险的极端温度的一个基本步骤。在本期《神经元》杂志中，达卡等人和科尔本等人报告称，缺乏冷和薄荷醇门控离子通道TRPM8的小鼠对低温的行为反应存在缺陷。