Department of Pharmaceutical Botany, Faculty of Pharmacy, Erciyes Unıversity, 38039 Kayseri, Turkey.
Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, 06330 Ankara, Turkey.
Molecules. 2020 Mar 30;25(7):1587. doi: 10.3390/molecules25071587.
L. species belong to the Asteraceae family and these plants are traditionally used for therapeutic purposes around the world. The dried milky latex of is known as "lettuce oil" and is used as a sedative in Turkey. This study aimed to evaluate the sedative effects and analyze the chemical compositions of latexes obtained from some species growing in Turkey. The sedative effects were evaluated through various behavioral tests on mice. For this purpose, latexes were obtained from Boiss., (L.) J. Presl and C. P, (Vis and Panćić) Boiss. and Kotschy ex. Boiss., L., and L. The latex from showed the highest sedative effects, whilst and latexes also displayed significant sedative effects compared to the control group at a dose of 100 mg/kg. However, the latexes from and did not exhibit any sedative effects on mice. Characteristic sesquiterpene lactones (lactucin, lactucopicrin, 11,13β-dihydrolactucin, and 11,13β-dihydrolactucopicrin) were determined qualitatively and quantitatively by high-performance liquid chromatography (HPLC). Lactucin was identified as the main component.
L. 物种属于菊科，这些植物在世界各地传统上被用于治疗用途。 的干燥乳白色乳胶被称为“生菜油”，在土耳其用作镇静剂。本研究旨在评估乳胶的镇静作用，并分析在土耳其生长的一些 L. 物种的乳胶的化学成分。通过对小鼠的各种行为测试来评估镇静作用。为此，从 Boiss.、（L.）J. Presl 和 C. P.、（Vis 和 Panćić）Boiss. 和 Kotschy ex. Boiss.、L. 和 L. 中获得了乳胶。来自 的乳胶表现出最高的镇静作用，而 100mg/kg 剂量的 和 乳胶与对照组相比也表现出显著的镇静作用。然而， 和 乳胶对小鼠没有镇静作用。通过高效液相色谱法（HPLC）定性和定量地确定了特征性倍半萜内酯（苦莴苣素、苦苣菜内酯、11,13β-二氢苦莴苣素和 11,13β-二氢苦苣菜内酯）。苦莴苣素被确定为主要成分。
