真核生物中辅酶Q的内源性合成。
Endogenous synthesis of coenzyme Q in eukaryotes.
作者信息
Tran UyenPhuong C, Clarke Catherine F
机构信息
Department of Chemistry and Biochemistry, Molecular Biology Institute, University of California, 607 Charles E. Young Drive East, Los Angeles, CA 90095-1569, USA.
出版信息
Mitochondrion. 2007 Jun;7 Suppl(Suppl):S62-71. doi: 10.1016/j.mito.2007.03.007. Epub 2007 Mar 30.
Abstract
Coenzyme Q (Q) functions in the mitochondrial respiratory chain and serves as a lipophilic antioxidant. There is increasing interest in the use of Q as a nutritional supplement. Although, the physiological significance of Q is extensively investigated in eukaryotes, ranging from yeast to human, the eukaryotic Q biosynthesis pathway is best characterized in the budding yeast Saccharomyces cerevisiae. At least ten genes (COQ1-COQ10) have been shown to be required for Q biosynthesis and function in respiration. This review highlights recent knowledge about the endogenous synthesis of Q in eukaryotes, with emphasis on S. cerevisiae as a model system.
摘要
辅酶Q（Q）在线粒体呼吸链中发挥作用，并作为一种亲脂性抗氧化剂。人们对将Q用作营养补充剂的兴趣与日俱增。尽管Q的生理意义在从酵母到人类的真核生物中得到了广泛研究，但真核生物Q生物合成途径在出芽酵母酿酒酵母中得到了最充分的表征。已证明至少十个基因（COQ1-COQ10）是Q生物合成和呼吸功能所必需的。本综述重点介绍了真核生物中Q内源性合成的最新知识，重点是以酿酒酵母作为模型系统。
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