Song In-Uk, Kim Joong-Seok, Jeong Du-Shin, Song Hyun-Joo, Lee Kwang-Soo
Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Parkinsonism Relat Disord. 2008 Nov;14(7):558-62. doi: 10.1016/j.parkreldis.2008.01.007. Epub 2008 Mar 6.
Parkinson's disease (PD) may exhibit patterns of cognitive deficits, yet physicians are currently lacking operational criteria to define the clinical boundaries between PD and PD dementia (PDD). Therefore, we investigated the characteristics of the cognitive impairments in mild PDD. We recruited 30 PDD, 20 PD-MCI (PD with mild cognitive impairment without dementia) and 33 controls. All subjects were evaluated with detailed neuropsychological tests. Our results showed that visual memory, visuospatial functions, naming and calculation displayed more marked impairment than that of the other domains. Thus we suggest that adding cognitive dysfunctions of cortical type to the early cognitive deficits of PD-MCI can help predict the development of dementia.
帕金森病（PD）可能会表现出认知缺陷模式，但目前医生缺乏定义PD与帕金森病痴呆（PDD）之间临床界限的操作标准。因此，我们研究了轻度PDD认知障碍的特征。我们招募了30例PDD患者、20例PD-MCI（轻度认知障碍但无痴呆的帕金森病患者）和33名对照者。所有受试者均接受了详细的神经心理学测试。我们的结果表明，视觉记忆、视觉空间功能、命名和计算方面的损害比其他领域更为明显。因此，我们建议在PD-MCI的早期认知缺陷基础上增加皮质型认知功能障碍，有助于预测痴呆的发展。
