Folope Vanessa, Coëffier Moïse, Déchelotte Pierre
Unité de Nutrition et groupe ADEN EA3234, IFR23, CHU de Rouen, Rouen, France.
Gastroenterol Clin Biol. 2007 Apr;31(4):369-77. doi: 10.1016/s0399-8320(07)89395-x.
Morbidly obese patients often have nutritional deficiencies, particularly in fat-soluble vitamins, folic acid and zinc. After bariatric surgery, these deficiencies may increase and others can appear, especially because of the limitation of food intake in gastric reduction surgery and of malabsorption in by-pass procedures. The latter result in more important weight loss but also increase the risk of more severe deficiencies. The protein deficiency associated with a decrease in the fat-free mass has been described in both procedures. It can sometimes require an enteral or parenteral support. Anemia can be secondary to iron deficiency, folic acid deficiency and even to vitamin B12 deficiency. Neurological disorders such as Gayet-Wernicke encephalopathy due to thiamine deficiency, or peripheral neuropathies may also be observed. Malabsorption of fat-soluble vitamins and other nutrients, especially if diagnosed after by-pass surgery, rarely cause clinical symptoms. However, some complications have been reported such as bone demineralization due to vitamin D deficiency, hair loss secondary to zinc deficiency or hemeralopia from vitamin A deficiency. A careful nutritional follow-up should be performed during pregnancy after obesity surgery, because possible deficiencies can affect the health of both the mother and child. In conclusion, increased awareness of the risk of deficiency and the systematic dosage of micronutrients are needed in the pre- and postoperative period in obese patients undergoing bariatric surgery. The case by case correction of these deficiencies is mandatory, and their systematic prevention should be evaluated.
病态肥胖患者常存在营养缺乏,尤其是脂溶性维生素、叶酸和锌缺乏。减肥手术后,这些缺乏可能会加重,还可能出现其他缺乏情况,特别是由于胃减容手术中食物摄入量受限以及旁路手术中的吸收不良。后者导致更显著的体重减轻,但也增加了更严重缺乏的风险。两种手术中均已描述了与去脂体重减少相关的蛋白质缺乏。有时可能需要肠内或肠外营养支持。贫血可能继发于缺铁、叶酸缺乏,甚至维生素B12缺乏。还可能观察到神经系统疾病,如因硫胺素缺乏导致的盖-韦脑病或周围神经病变。脂溶性维生素和其他营养素的吸收不良,尤其是在旁路手术后被诊断出时,很少引起临床症状。然而,已报告了一些并发症,如维生素D缺乏导致的骨质脱矿、锌缺乏继发的脱发或维生素A缺乏引起的夜盲。肥胖手术后的孕期应进行仔细的营养随访,因为可能的缺乏会影响母婴健康。总之,接受减肥手术的肥胖患者在术前和术后阶段需要提高对缺乏风险的认识并系统检测微量营养素。针对这些缺乏情况逐例进行纠正必不可少,同时应评估对其进行系统预防的措施。