Buitrago Salassa Carolina, Javier Lespi Pablo
Servicio de Patologia, Hospital Interzonal Dr. J. Penna, Bahía Blanca, Argentina.
Acta Gastroenterol Latinoam. 2007 Mar;37(1):11-4.
BACKGROUND/AIM: In this paper we present a histological and histochemical study about the metaplastic changes in the gallbladder, and discussed the participation of the antral metaplasia in the genesis of gallbladder cancer.
We collected 43 pieces of colecistectomy whit antral metaplasia, intestinal metaplasia and displasia. Presence of mucins were demonstrated by the alcian blue stain to ph 3 and ph 0.5 ph.
We found sulphated and not sulphated acid mucins. In all of the forms of antral metaplasia. The not freguent finding coas an intense staining of intracitoplasmie mucins in metaplastic cells. We alsa detected small globular deposits in isolated cells of surface epithelium.
This finding seems to associate antral metaplasia with intestinal metaplasia, at least in the mucins production. Antral metaplasia could be one of the first steps involved in the sequence displasia-cancer in the gallbladder.
背景/目的：本文展示了一项关于胆囊化生改变的组织学和组织化学研究，并探讨了胃窦化生在胆囊癌发生中的作用。
我们收集了43份伴有胃窦化生、肠化生和发育异常的胆囊切除术标本。通过pH 3和pH 0.5的阿尔辛蓝染色来显示黏蛋白的存在。
我们发现了硫酸化和非硫酸化酸性黏蛋白。在所有胃窦化生形式中，不常见的发现是化生细胞中胞质内黏蛋白的强烈染色。我们还在表面上皮的孤立细胞中检测到小的球状沉积物。
这一发现似乎表明胃窦化生与肠化生有关，至少在黏蛋白产生方面。胃窦化生可能是胆囊发育异常-癌症序列中最初的步骤之一。
