Tatematsu M, Furihata C, Miki K, Ichinose M, Shirai T, Tatematsu K, Ito N
Acta Pathol Jpn. 1987 Jan;37(1):39-46. doi: 10.1111/j.1440-1827.1987.tb03132.x.
The features of pyloric gland metaplasia in the gallbladder epithelium were studied by histochemical staining for mucin and the immunoperoxidase method for pepsinogens (Pg) I and II. Pyloric gland metaplasia was found in 48 of 72 gallbladders removed surgically. All the pyloric gland metaplastic cells contained class III mucin demonstrated by paradoxical concanavalin A (Con A) staining. Pyloric gland metaplasia was classified into complete and incomplete types on the basis of the immunohistochemical reactivities of Pgs I and II: The complete type of pyloric gland metaplasia contained neutral mucins and weak Pg I and strong Pg II activities, like normal pyloric gland cells. Almost all specimens of the incomplete type of pyloric gland metaplasia contained acid mucins and were further classified into two types: an incomplete type 1, which had Pg II but no Pg I activity, and an incomplete type 2, which had no Pg I or II activity.
通过对黏蛋白进行组织化学染色以及对胃蛋白酶原（Pg）I和II进行免疫过氧化物酶法，研究了胆囊上皮中幽门腺化生的特征。在手术切除的72个胆囊中，有48个发现了幽门腺化生。所有幽门腺化生细胞均含有通过伴刀豆球蛋白A（Con A）反常染色显示的III类黏蛋白。根据Pg I和II的免疫组化反应性，幽门腺化生分为完全型和不完全型：完全型幽门腺化生含有中性黏蛋白，胃蛋白酶原I活性弱，胃蛋白酶原II活性强，类似于正常幽门腺细胞。几乎所有不完全型幽门腺化生标本都含有酸性黏蛋白，并进一步分为两种类型：不完全1型，有胃蛋白酶原II活性但无胃蛋白酶原I活性；不完全2型，无胃蛋白酶原I或II活性。
