Flood A, Mai V, Pfeiffer R, Kahle L, Remaley A T, Rosen C J, Lanza E, Schatzkin A
Division of Epidemiology, University of Minnesota, Minneapolis, MN 55454, USA.
Eur J Clin Nutr. 2008 Feb;62(2):186-96. doi: 10.1038/sj.ejcn.1602726. Epub 2007 May 9.
To determine the effects of dietary change on serum concentrations of insulin, glucose, IGF-I and IGFBP-3.
From among participants in a randomized clinical trial of men and women without a history of diabetes who were 35 years old or older and who had at least one histologically confirmed colorectal adenoma removed during a qualifying colonoscopy within the 6 months before randomization, 750 subjects were selected for this analysis.
The authors analyzed fasting serum from 375 subjects with and 375 subjects without a recurrent polyp among participants in a randomized trial of a low-fat (20% of energy), high-fiber (18 g per 1000 kcals of energy intake) and high-fruit and -vegetable (5-8 servings per day) dietary intervention.
After 4 years of follow-up, IGF-I concentration in the intervention group (N=248) declined by 8.86 ng/ml (initial mean of 133 ng/ml) and 7.74 ng/ml (initial mean value of 139 ng/ml) in the non-intervention group (N=502). Based on an unpaired t-test, these declines were both statistically significant, but the difference between groups for the decline in IGF-I (1.12 ng/ml ((95% confidence interval, -3.24 to 5.48)) was not. After 4 years, concentrations of IGFBP-3, insulin and glucose were not statistically different from values at baseline, and there were no differences in these serum measures between the intervention and control groups. In analysis restricted to lean (body mass index <25 kg/m(2)) subjects only, however, glucose concentrations in the intervention group decreased by 0.28 mmol/l, while they increased in the control group by 0.01 mmol/l (t-test for mean differences P=0.0003) over 4 years.
A low-fat, high-fiber, high-fruit and -vegetable dietary intervention had minimal impact on serum concentrations of insulin, glucose, IGF-I and IGFBP-3 overall, but in lean subjects the intervention resulted in a significant reduction in serum glucose concentration.
确定饮食变化对胰岛素、葡萄糖、胰岛素样生长因子-I（IGF-I）和胰岛素样生长因子结合蛋白-3（IGFBP-3）血清浓度的影响。
从一项随机临床试验的参与者中选取，这些参与者为35岁及以上、无糖尿病病史的男性和女性，且在随机分组前6个月内进行的一次符合条件的结肠镜检查中至少切除过一个经组织学确诊的结肠腺瘤，共750名受试者被选入本分析。
作者分析了一项低脂（占能量的20%）、高纤维（每1000千卡能量摄入含18克纤维）和高果蔬（每天5 - 8份）饮食干预随机试验参与者中375名有复发性息肉受试者和375名无复发性息肉受试者的空腹血清。
经过4年随访，干预组（N = 248）的IGF-I浓度下降了8.86 ng/ml（初始平均值为133 ng/ml），非干预组（N = 502）下降了7.74 ng/ml（初始平均值为139 ng/ml）。基于未配对t检验，这些下降均具有统计学意义，但两组间IGF-I下降幅度的差异（1.12 ng/ml（95%置信区间，-3.24至5.48））无统计学意义。4年后，IGFBP-3、胰岛素和葡萄糖的浓度与基线值无统计学差异，干预组和对照组之间这些血清指标也无差异。然而，仅在对瘦人（体重指数<25 kg/m²）的分析中，干预组的葡萄糖浓度在4年中下降了0.28 mmol/l，而对照组上升了0.01 mmol/l（平均差异t检验P = 0.0003）。
低脂、高纤维、高果蔬饮食干预总体上对胰岛素、葡萄糖、IGF-I和IGFBP-3的血清浓度影响极小，但在瘦人受试者中，该干预导致血清葡萄糖浓度显著降低。
