Dai Xi, Li Run-Ze, Jiang Ze-Bo, Wei Chun-Li, Luo Lian-Xiang, Yao Xiao-Jun, Li Guo-Ping, Leung Elaine L-H
State Key Laboratory of Quality Research in Chinese Medicines, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau, China.
Department of Respiratory Medicine, Affiliated Hospital of Southwest Medical University, Luzhou, China.
Front Pharmacol. 2018 May 28;9:558. doi: 10.3389/fphar.2018.00558. eCollection 2018.
Honokiol is a natural compound with small molecular structure and extracted from bark of magnolia trees. The biological activities of honokiol include anti-oxidation, anti-inflammation as well as anti-tumor. However, their mechanism remains unknown. In this study, A549 cell line and EGFR-mutant cell line PC-9 with higher expression level of Lyn than A549 cells were used to assess the anti-tumor effects of honokiol. As shown in this study, honokiol is an effective drug on inhibiting proliferation and inducing apoptosis depended on Lyn and EGFR signal pathway regulated by Lyn, and its efficacy is stronger in PC-9 cells than A549 cells. In addition, this anti-tumor effect in PC-9 cells was weakened by Lyn-knockdown. Taken together, this study indicated the mechanism of honokiol on lung adenocarcinoma and provides a possibility of honokiol as an effective anti-tumor medicine.
厚朴酚是一种具有小分子结构的天然化合物，从木兰树皮中提取。厚朴酚的生物活性包括抗氧化、抗炎以及抗肿瘤。然而，其作用机制仍不清楚。在本研究中，使用A549细胞系以及Lyn表达水平高于A549细胞的EGFR突变细胞系PC-9来评估厚朴酚的抗肿瘤作用。如本研究所示，厚朴酚是一种依赖Lyn以及由Lyn调节的EGFR信号通路来抑制增殖和诱导凋亡的有效药物，其在PC-9细胞中的疗效强于A549细胞。此外，PC-9细胞中的这种抗肿瘤作用因Lyn基因敲低而减弱。综上所述，本研究阐明了厚朴酚对肺腺癌的作用机制，并为厚朴酚作为一种有效的抗肿瘤药物提供了可能性。
