Tschoppe P, Meyer-Lueckel H, Toll R, Kielbassa A M
Poliklinik für Zahnerhaltungskunde und Parodontologie, Campus Benjamin Franklin, Charité Centrum 3 für Zahn-, Mund- und Kieferheilkunde, Charité--Universitätsmedizin Berlin.
Laryngorhinootologie. 2007 Oct;86(10):723-7. doi: 10.1055/s-2007-966495. Epub 2007 May 8.
Hyposalivation is an important chronic side effect of radiotherapy in the head and neck area, and patients often alleviate their symptoms using saliva substitutes. The aim of this study was to evaluate the effects of two commercially available saliva substitutes (Saliva natura and Glandosane) on the mineral loss of bovine enamel and dentin in vitro. An aqueous remineralization solution served as control.
Each 45 bovine enamel and dentin specimens were prepared. Prior to (control of sound dentin) and after (control of demineralized dentin) demineralization (37 degrees C; enamel: pH 4.95; 14 d; dentin: pH 5.0; 7 d) one third of each specimens surface was covered with nail varnish. Subsequently, the specimens (n = 15) were exposed to Glandosane and Saliva natura as well as a remineralization solution for 14 days (37 degrees C). Specimens were examined using transversal microradiography.
Compared to Saliva natura and the reminerlization solution, Glandosane induced both significantly increased mineral losses as well as lesion depths of the enamel specimens (p < 0.05; ANOVA, Bonferroni). After exposure of the dentin specimens to Saliva natura a significantly increased mineral loss could be observed (p < 0.001), whereas no differences in mineral loss could be observed for the enamel specimens (p = 0.078; t-test).
Within the limitations of an in vitro study it can be concluded that Glandosane revealed a demineralizing potential on bovine enamel as well as on dentin and should not be recommended for dentate patients. Since Saliva natura has a demineralizing effect on dentin, a further improvement regarding the remineralizing capacity would be desirable.
唾液分泌减少是头颈部放疗的一种重要慢性副作用，患者常使用唾液替代品缓解症状。本研究旨在体外评估两种市售唾液替代品（Saliva natura和Glandosane）对牛牙釉质和牙本质矿物质流失的影响。以一种矿化再补充溶液作为对照。
制备45个牛牙釉质和牙本质样本。在脱矿（37℃；牙釉质：pH 4.95；14天；牙本质：pH 5.0；7天）之前（健康牙本质对照）和之后（脱矿牙本质对照），每个样本表面的三分之一用指甲油覆盖。随后，将样本（n = 15）暴露于Glandosane、Saliva natura以及一种矿化再补充溶液中14天（37℃）。使用横向显微放射照相术检查样本。
与Saliva natura和矿化再补充溶液相比，Glandosane导致牙釉质样本的矿物质流失和病变深度均显著增加（p < 0.05；方差分析，Bonferroni检验）。牙本质样本暴露于Saliva natura后可观察到矿物质流失显著增加（p < 0.001），而牙釉质样本的矿物质流失未观察到差异（p = 0.078；t检验）。
在体外研究的局限性内，可以得出结论，Glandosane对牛牙釉质和牙本质均显示出脱矿潜力，不建议用于有牙患者。由于Saliva natura对牙本质有脱矿作用，其矿化再补充能力还有进一步提升的空间。
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