通过模板合成法制备的可生物降解聚（ε-己内酯）纳米线和纳米纤维的排列阵列。

Aligned arrays of biodegradable poly(epsilon-caprolactone) nanowires and nanofibers by template synthesis.

作者信息

Tao Sarah L, Desai Tejal A

机构信息

Department or Physiology, University of California, San Francisco, 1700 4th Street, San Francisco, California 94143, USA.

出版信息

Nano Lett. 2007 Jun;7(6):1463-8. doi: 10.1021/nl0700346. Epub 2007 May 8.

DOI:10.1021/nl0700346

PMID:17488047

Abstract

We demonstrate that the technically simple, low-cost, and rapid method of template synthesis can be used to create arrays of nanowires and nanofibers from the biocompatible, biodegradable polymer poly(epsilon-caprolactone) (PCL). PCL substrates introduced into a standard laboratory oven at temperatures as low as 65 degrees C are able to form nanostructures. Nanostructure morphology can be controlled, and complex patterning can be achieved. Solvent-free and low-temperature fabrications also allow for the encapsulation of therapeutics for sustained release.

摘要

我们证明，模板合成这种技术简单、成本低且快速的方法可用于从生物相容性、可生物降解的聚合物聚（ε-己内酯）（PCL）制备纳米线和纳米纤维阵列。引入到标准实验室烘箱中、温度低至65摄氏度的PCL底物能够形成纳米结构。纳米结构形态可以得到控制，并且能够实现复杂的图案化。无溶剂和低温制造还允许对治疗剂进行封装以实现持续释放。